Each quarter, UCLA undergraduate science students showcase the research they have done. We would like to invite you to see our students in action and to share your professional expertise during the Winter 2019 MIMG/MCDB Undergraduate Research Poster Symposium.
Date: Friday March 15th, 2019
Time: 2:00 – 4:00 PM
Good Weather: Molecular Sciences Bldg. Patio
Poor Weather: Life Sciences Bldg. rm 2320
Program Overview: Showcases and celebrates undergraduate student research and allows students to present their work to the campus and broader community. Students will present the results of their work conducted this year in the following laboratory programs:
– MIMG 103BL – Advanced Research Analysis in Virology: Characterization and Genomic Analysis of Novel Bacteriophages
– MIMG 109BL – Advanced Research Analysis in Microbiology: Agricultural Impacts on Soil Microbial Communities
– MCDB 150L – Research Immersion Laboratory in Plant-Microbe Ecology: Plant Growth Promotion in Diverse Soils
Your Role: Give students an opportunity to share their research and to practice and strengthen their public speaking skills. Your role is to listen to student poster talks and provide students with feedback on their work and presentations.
Abstract: The adoptive transfer of T cells expressing chimeric antigen receptors (CARs) has demonstrated clinical efficacy in the treatment of advanced cancers, with anti-CD19 CAR-T cells achieving up to 90% complete remission among patients with relapsed B-cell malignancies. However, challenges such as antigen escape and immunosuppression limit the long-term efficacy of adoptive T-cell therapy. Here, I will discuss the development of next-generation T cells that can target multiple cancer antigens and resist immunosuppression, thereby increasing the robustness of therapeutic T cells against tumor defense mechanisms. Specifically, I will discuss the development of multi-input receptors and T cells that can interrogate intracellular antigens. I will also discuss the engineering of T cells that can effectively convert TGF-beta from a potent immunosuppressive cytokine into a T-cell stimulant. This presentation will highlight the potential of synthetic biology in generating novel mammalian cell systems with multifunctional outputs for therapeutic applications.