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Upcoming Events

Mar
28
Thu
“Engineering Next-Generation T Cells for Cancer Immunotherapy” Seminar by Yvonne Y. Chen, Ph.D. @ Molecular Science Building 1601 Conference Room
Mar 28 @ 2:00 pm – 3:00 pm

Abstract: The adoptive transfer of T cells expressing chimeric antigen receptors (CARs) has demonstrated clinical efficacy in the treatment of advanced cancers, with anti-CD19 CAR-T cells achieving up to 90% complete remission among patients with relapsed B-cell malignancies. However, challenges such as antigen escape and immunosuppression limit the long-term efficacy of adoptive T-cell therapy. Here, I will discuss the development of next-generation T cells that can target multiple cancer antigens and resist immunosuppression, thereby increasing the robustness of therapeutic T cells against tumor defense mechanisms. Specifically, I will discuss the development of multi-input receptors and T cells that can interrogate intracellular antigens. I will also discuss the engineering of T cells that can effectively convert TGF-beta from a potent immunosuppressive cytokine into a T-cell stimulant. This presentation will highlight the potential of synthetic biology in generating novel mammalian cell systems with multifunctional outputs for therapeutic applications.

Selected Publications

-More than 50 undergraduate authors from the MIMG Research Immersion in Virology curriculum recently published a peer-reviewed article announcing the fully annotated genomes of six novel bacteriophages they isolated on Mycobacterium smegmatis. See the full publication here.