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MIMG
Arnold Berk, M.D.
Molecular mechanisms regulating transcription
My lab studies the molecular interactions that regulate transcription in mammalian cells, focusing particular attention on transcription factors encoded by oncogenes and tumor suppressors. The decision to initiate transcription of a gene is the key control point regulating its expression ...(more)
Irvin Chen, Ph.D.
AIDS & cancer causes and therapy, viruses, gene therapy
The overall research interests of this laboratory are to understand, at the molecular and cellular levels, how the human retroviruses, human immunodeficiency virus (HIV) and human T-cell leukemia virus (HTLV), cause AIDS and cancer, respectively. We are also developing ...(more)
Asim Dasgupta, Ph.D.
Molecular Biology of Small Mammalian RNA Viruses
Our laboratory is studying the molecular biology of small mammalian RNA viruses. These viruses called picornaviruses include those inducing common cold (rhinoviruses), poliomyelitis, (poliovirus), infectious hepatitis (hepatitis A), encephalitis and juvenile diabetes ...(more)
Fred Eiserling, Ph.D.
Structural studies of virus assembly
Our lab uses the bacterial virus T4 to explore problems in cell biology related to control of shape and size of subcellular organelles. Our research is aimed at understanding more fully the shape and size determining mechanisms in morphogenesis using bacteriophages as an ...(more)
Lawrence Feldman, Ph.D.
Molecular Aspects of Herpes Virus Infection
The laboratory is investigating the molecular aspects of Herpes simplex virus latency in a mouse and rabbit model. In the mouse model, the promoter for the LAT (latency associated) transcript has been identified, and efforts to map the transcription factor sites for neuronal ...(more)
Benhur Lee, M.D.
Viral Attachment and Entry, HIV and Emerging Viruses, Glycobiology
Viral envelope glycoproteins are highly glycosylated structures that interact with various cell surface receptors. My lab places emphasis on the mechanisms of viral entry and membrane fusion, focusing on the interaction of the viral envelope with cell surface receptors. ...(more)
Debi Nayak, B.V.Sc., Ph.D.
Molecular Biology Influenza (Orthomyxo) and Sendai (Paramyxo) Viruses
Major research effort in Dr. Nayak’s lab is directed towards understanding the molecular basis of viral pathogenesis with special emphasis on pathogenesis, replication, assembly, morphogenesis and budding of influenza, Sendai and HIV viruses. Current projects ...(more)
Z. Hong Zhou, Ph.D.
Cryo-electron microscopy and computer reconstruction
Professor Hong Zhou’s lab focuses on establishing structure-function relationships in viruses and supra-molecular complexes using cryo-electron microscopy (cryoEM) and three-dimensional (3D) computer reconstruction techniques. This technique is particularly suited to macromolecular complexes that are ... (more)
