Benjamin Bonavida, Ph.D.
Resistance and the induction of apoptosis in tumor cells
Our research interests have focused in areas of both cellular and molecular immunology as they relate to infection and cancer. During the last several years the laboratory has focused on two areas of research investigations: (1) The molecular mechanism by which rituximab ...(more)
David G. Brooks, Ph.D.
Immune Mechanisms of Virus Clearance and Persistence
Persistent viral infections are one of the greatest health concerns worldwide and the treatment of these infections represents a major challenge to medical science. T cell responses are crucial to prevent and control viral infections. However, T cell activity is rapidly lost following persistent viral ...(more)
John Fahey, M.D.
The research activities focus on understanding the immune system disorders of disease and the effects of immune-based therapies. Cytokine dysregulation in HIV infection with deficiencies of IL-2, excessive interferon-gamma, altered regulatory cytokines and monocyte/macrophage ...(more)
Donald B. Kohn, M.D.
My research focuses on efforts to develop gene therapy methods for diseases of the hematopoietic and immunologic systems. Basic research studies the development of gene delivery vectors, focusing on methods to achieve more effective gene transfer into human hematopoietic stem cells ...(more)
Otoniel Martinez-Maza, Ph.D.
Immune Dysfunction and Cancer; AIDS Pathogenesis
We are interested in better understanding the role of immune dysfunction in the genesis and growth of human cancer. Current work is focusing on better defining the role of HIV infection-associated immune dysfunction in the development and growth of AIDS-associated cancers ...(more)
Carrie Miceli, Ph.D.
T Cell Activation and Inactivation
T cells utilize the T cell receptor (TCR) to specifically recognize antigen in association with self MHC and to signal one of several distinct responses. Under different circumstances, a T cell responds to TCR stimulation by proliferating, differentiating along a particular developmental ...(more)
Robert Modlin, M.D.
Infectious disease poses a major health problem worldwide. Essential to control of these diseases is the elucidation of immune mechanisms which result in resistance versus susceptibility to infection. Our laboratory's focus is the identification of novel mechanisms ...(more)
Sherie Morrison, Ph.D.
Genetic engineering and gene transfection of antibodies
In 1982 our laboratory developed the methods for expressing antibody genes in lymphoid cells. This technology both enabled us to identify lymphoid specific controlling elements(enhancers) and to produce genetically engineered antibodies in the appropriate cellular environment ...(more)
Stephen Smale, Ph.D.
Gene Regulation Mechanisms Controlling Inflammatory Responses, Innate Immune Responses, and Lymphocyte Differentiation from Embryonic Stem Cells
Our laboratory has broad interests in the molecular mechanisms of gene regulation in cells of the immune system. Two areas of interest are summarized below ...(more)
Ronald Stevens, Ph.D.
Ronald H. Stevens is designing testing materials that employ pattern recognition to help students profit from success and learn from their mistakes. The Interactive Multi Media Exercises (IMMEX) software system, now used for problem solving in science curriculums from ...(more)
Christel Uittenbogaart, M.D.
Human T Cell Development
Human T cell development is the major focus of the laboratory. The thymus is the central organ where T cell receptor (TCR) alpha/beta cells as well as other rare hematopoietic cell types develop from intrathymic stem cells. These cell types include TCR gamma/delta cells ...(more)
Randolph Wall, Ph.D.
Genes and Mechanisms Controlling B Lymphocyte Development The stages in B lymphocyte development are delineated by the activation and transcription of immunoglobulin genes and other tissue-specific genes. Research in the Wall lab is directed at discovering the molecular ...(more)
Jerome Zack, Ph.D.
Pathogenic processes of HIV-1 infection
My interests are in the pathogenic processes of HIV-1 infection. My laboratory concentrates on developing model systems which are more relevant to the pathogenic process in man than are standard in vitro culture approaches, with the eventual goal of using these systems to ...(more)