Genes and Mechanisms Controlling B Lymphocyte Development The stages in B lymphocyte development are delineated by the activation and transcription of immunoglobulin genes and other tissue-specific genes. Research in the Wall lab is directed at discovering the molecular mechanisms which control B cell development by the cloning of B-cell-specific genes and the characterization of their function and regulation. The best studied B-cell-specific gene identified here (B29) codes for a critical member of the antigen receptor complex on B cells and is essential for B cell activation and development. Transcription factors shown to control the B29 promoter are now known to regulate the appearance of the earliest committed lymphoid precursor cells. B29 expression is critical for development of the earliest B lineage precursors (i.e. proB ÃÂ¨ pre B cells). Aberrant expression of the B29 gene is implicated in human chronic lymphocytic leukemia (B-CLL). Another area of active research in this Lab is directed at resolving the cytokines, signalling events and transcription factors which activate and control immunoglobulin gene expression in B-cell development. This research uses the combined approaches of molecular biology, immunology and genetics.
Patrone L, Henson SE, Teodorovic J, Malone CS, French SW, Wall R, Teitell MA Gene expression patterns in AIDS versus non-AIDS-related diffuse large B-cell lymphomaExp Mol Pathol, 2003; 74(2): 129-39.
Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC, Teitell MA Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma
Proceedings of the National Academy of Sciences of the United States of America. , 2002; 99(22): 14392-7.
Malone CS and Wall R Bob1 (OCA-B/OBF-1) differential transactivation of the B cell-specific TATA-less B29 (Ig-beta) and mb-1 (Ig-alpha) gene promoters, Journal of Immunology, 2002; 168: 3369-3375.
Gordon MS, Kato RM, Lansigan F, Thompson AA, Wall R, Rawlings DJ Aberrant B cell receptor signalling from B29 (Ig-beta, CD79b) gene mutations of chronic lymphocytic leukemia B cells, Proceedings of the National Academy of Sciences, 2000; 97 (10): 5504-5509.
Malone CS, Patrone L, Wall R An essential octamer motif in the mb-1 (Ig-alpha) promoter, Molecular Immunology, 2000; 37: 321-328.
Thompson AA, Talley JA, Do NH, Kagan HL, Kunkel L, Berenson J, Cooper MD, Saxon A and Wall R Aberrations of the B cell receptor B29 (CD79b) gene in chronic lymphocytic leukemia, Blood, 1997; 90: 1387-1394.
Omori SA, Smale S, O’Shea-Greenfield A and Wall R Differential interaction of nuclear factors with the leukocyte-specific pp52 promoter in B and T cells, J. Immunol, 1997; 159: 1800-1808.
Malone CS, Omori SA and Wall R Silencer elements controlling the B29 (IgB) promoter are neither promoter- nor cell-type specific, Proc. Nat. Acad. Sci. USA, 1997; 94: 12314-12319.
Damore MA, Omori SA, Wall R INF-gamma induces the Kappa intron enhancer via an IFN-stimulated response element, Journal of Immunology, 1996; 156: 2451-2457.
Thompson AA, Omori SA, Gilly MJ, May W, Gordon MS, Wood WJ, Miyoshi E, Malone CS, Gimble J, Denny CT, Wall R Alternatively spliced exons encode the tissue-specific 5′ termini of leukocyte pp52 and stromal cell S37 mRNA isoforms
Genomics. , 1996; 32(3): 352-7.