University Professor, University of California
Director, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research
Member, JCCC Genitourinary Oncology Program Area
Our research interests center on understanding cancer pathogenesis and the immune response as a way to define new targets for therapy. Past work has defined the family of tyrosine kinase enzymes including Bcr-Abl and its role in human Chronic Myelogenous Leukemia and Bruton’s tyrosine kinase as regulator of lymphocyte growth control. This has helped enable the development of drugs like Imatinib and Ibrutinib now used in the treatment of multiple leukemias, lymphomas, and other cancers. More recent research has centered on epithelial cancers including prostate cancer. We have defined surface antigens like PSCA and others as targets for monoclonal antibody or chimeric antigen receptor T cell mediated therapy. A fundamental understanding of normal prostate development and stem cells is used as a comparison to the process of prostate cancer development, metastasis, and conversion to its aggressive castration resistant form. We have defined specific kinases and their pathways that point towards new targets for therapy, as well as a developmental change of tumors in response to therapy that drives the evolution of a very aggressive small cell histology with neuroendocrine features. In many of our studies we employ advanced imaging technologies including Positron Emission Tomography to monitor specific cell populations and aspects of tumor and immune response metabolism.
Owen Witte received his undergraduate degree from Cornell and his MD from Stanford University. He completed postdoctoral research at MIT then joined the faculty at UCLA where he presently is a University Professor of Microbiology, Immunology and Molecular Genetics and holds the President’s Chair in Developmental Immunology. He is the Director of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA. Dr. Witte is a member of the National Academy of Sciences, the American Academy of Arts and Sciences, and the Institute of Medicine. He has received recognition for his research including the Milken Foundation Award in Basic Cancer Research, the Rosenthal Award of the American Association for Cancer Research, the Dameshek Prize of the American Society of Hematology, the Alpert Foundation Prize, The Leukemia and Lymphoma Society’s de Villiers International Achievement Award, the UCLA Faculty Research Lecture, the Nakahara Memorial Lecture Prize, the AACR G.H.A. Clowes Memorial Award, the AAMC Award for Distinguished Research in Biomedical Sciences and the Stanford Medical School Kornberg-Berg Lifetime Achievement Award in Biosciences. He currently serves on several editorial and advisory boards. Dr. Witte previously served on the Board of Directors for the American Association for Cancer Research. He was also appointed by President Obama to the President’s Cancer Panel from 2012-2017
Stoyanova Tanya, Riedinger Mireille, Lin Shu, Faltermeier Claire M, Smith Bryan A, Zhang Kelvin X, Going Catherine C, Goldstein Andrew S, Lee John K, Drake Justin M, Rice Meghan A, Hsu En-Chi, Nowroozizadeh Behdokht, Castor Brandon, Orellana Sandra Y, Blum Steven M, Cheng Donghui, Pienta Kenneth J, Reiter Robert E, Pitteri Sharon J, Huang Jiaoti, Witte Owen N Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proceedings of the National Academy of Sciences of the United States of America
. 2016; 113(42): E6457-E6466.
Drake Justin M, Paull Evan O, Graham Nicholas A, Lee John K, Smith Bryan A, Titz Bjoern, Stoyanova Tanya, Faltermeier Claire M, Uzunangelov Vladislav, Carlin Daniel E, Fleming Daniel Teo, Wong Christopher K, Newton Yulia, Sudha Sud, Vashisht Ajay A, Huang Jiaoti, Wohlschlegel James A, Graeber Thomas G, Witte Owen N, Stuart Joshua M Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer. Cell
. 2016; 166(4): 1041-54.
Lee John K, Phillips John W, Smith Bryan A, Park Jung Wook, Stoyanova Tanya, McCaffrey Erin F, Baertsch Robert, Sokolov Artem, Meyerowitz Justin G, Mathis Colleen, Cheng Donghui, Stuart Joshua M, Shokat Kevan M, Gustafson W Clay, Huang Jiaoti, Witte Owen N N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer cell
. 2016; 29(4): 536-47.
Kim Woosuk, Le Thuc M, Wei Liu, Poddar Soumya, Bazzy Jimmy, Wang Xuemeng, Uong Nhu T, Abt Evan R, Capri Joseph R, Austin Wayne R, Van Valkenburgh Juno S, Steele Dalton, Gipson Raymond M, Slavik Roger, Cabebe Anthony E, Taechariyakul Thotsophon, Yaghoubi Shahriar S, Lee Jason T, Sadeghi Saman, Lavie Arnon, Faull Kym F, Witte Owen N, Donahue Timothy R, Phelps Michael E, Herschman Harvey R, Herrmann Ken, Czernin Johannes, Radu Caius G [18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity. Proceedings of the National Academy of Sciences of the United States of America
. 2016; 113(15): 4027-32.
TavarÃ© Richard, Escuin-Ordinas Helena, Mok Stephen, McCracken Melissa N, Zettlitz Kirstin A, Salazar Felix B, Witte Owen N, Ribas Antoni, Wu Anna M An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy. Cancer research
. 2016; 76(1): 73-82.
Faltermeier Claire M, Drake Justin M, Clark Peter M, Smith Bryan A, Zong Yang, Volpe Carmen, Mathis Colleen, Morrissey Colm, Castor Brandon, Huang Jiaoti, Witte Owen N Functional screen identifies kinases driving prostate cancer visceral and bone metastasis. Proceedings of the National Academy of Sciences of the United States of America
. 2016; 113(2): E172-81.
Zong Yang, Goldstein Andrew S, Witte Owen N Tissue Recombination Models for the Study of Epithelial Cancer. Cold Spring Harbor protocols
. 2015; 2015(12): pdb.top069880.
Zong Yang, Goldstein Andrew S, Witte Owen N Dissociated Prostate Regeneration under the Renal Capsule. Cold Spring Harbor protocols
. 2015; 2015(11): 991-4.
Sharma Arun, Sebastiano Vittorio, Scott Christopher T, Magnus David, Koyano-Nakagawa Naoko, Garry Daniel J, Witte Owen N, Nakauchi Hiromitsu, Wu Joseph C, Weissman Irving L, Wu Sean M Lift NIH restrictions on chimera research. Science (New York, N.Y.)
. 2015; 350(6261): 640.
Zong Yang, Goldstein Andrew S, Witte Owen N Preparation of Urogenital Sinus Mesenchymal Cells for Prostate Tissue Recombination Models. Cold Spring Harbor protocols
. 2015; 2015(11): 988-90.
Goodwin Jonathan F, Kothari Vishal, Drake Justin M, Zhao Shuang, Dylgjeri Emanuela, Dean Jeffry L, Schiewer Matthew J, McNair Christopher, Jones Jennifer K, Aytes Alvaro, Magee Michael S, Snook Adam E, Zhu Ziqi, Den Robert B, Birbe Ruth C, Gomella Leonard G, Graham Nicholas A, Vashisht Ajay A, Wohlschlegel James A, Graeber Thomas G, Karnes R Jeffrey, Takhar Mandeep, Davicioni Elai, Tomlins Scott A, Abate-Shen Cory, Sharifi Nima, Witte Owen N, Feng Felix Y, Knudsen Karen E DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis. Cancer cell
. 2015; 28(1): 97-113.
Evdokimov Nikolai M, Clark Peter M, Flores Graciela, Chai Timothy, Faull Kym F, Phelps Michael E, Witte Owen N, Jung Michael E Development of 2-Deoxy-2-[(18)F]fluororibose for Positron Emission Tomography Imaging Liver Function in Vivo. Journal of medicinal chemistry
. 2015; 58(14): 5538-47.
McCracken Melissa N, Vatakis Dimitrios N, Dixit Dhaval, McLaughlin Jami, Zack Jerome A, Witte Owen N Noninvasive detection of tumor-infiltrating T cells by PET reporter imaging. The Journal of clinical investigation
. 2015; 125(5): 1815-26.
Gschweng Eric H, McCracken Melissa N, Kaufman Michael L, Ho Michelle, Hollis Roger P, Wang Xiaoyan, Saini Navdeep, Koya Richard C, Chodon Thinle, Ribas Antoni, Witte Owen N, Kohn Donald B HSV-sr39TK positron emission tomography and suicide gene elimination of human hematopoietic stem cells and their progeny in humanized mice. Cancer research
. 2014; 74(18): 5173-83.
Clark Peter M, Flores Graciela, Evdokimov Nikolai M, McCracken Melissa N, Chai Timothy, Nair-Gill Evan, O’Mahony Fiona, Beaven Simon W, Faull Kym F, Phelps Michael E, Jung Michael E, Witte Owen N Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver.Proceedings of the National Academy of Sciences of the United States of America
. 2014; 111(28): E2866-74.
Chodon Thinle, Comin-Anduix BegoÃ±a, Chmielowski Bartosz, Koya Richard C, Wu Zhongqi, Auerbach Martin, Ng Charles, Avramis Earl, Seja Elizabeth, Villanueva Arturo, McCannel Tara A, Ishiyama Akira, Czernin Johannes, Radu Caius G, Wang Xiaoyan, Gjertson David W, Cochran Alistair J, Cornetta Kenneth, Wong Deborah J L, Kaplan-Lefko Paula, Hamid Omid, Samlowski Wolfram, Cohen Peter A, Daniels Gregory A, Mukherji Bijay, Yang Lili, Zack Jerome A, Kohn Donald B, Heath James R, Glaspy John A, Witte Owen N, Baltimore David, Economou James S, Ribas Antoni Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research
. 2014; 20(9): 2457-65.
Drake Justin M, Lee John K, Witte Owen N Clinical targeting of mutated and wild-type protein tyrosine kinases in cancer. Molecular and cellular biology
. 2014; 34(10): 1722-32.
Bunimovich Yuri L, Nair-Gill Evan, Riedinger Mireille, McCracken Melissa N, Cheng Donghui, McLaughlin Jami, Radu Caius G, Witte Owen N Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance. PloS one
. 2014; 9(8): e104125.
Janzen Deanna M, Paik Daniel Y, Rosales Miguel A, Yep Brian, Cheng Donghui, Witte Owen N, Kayadibi Huseyin, Ryan Christopher M, Jung Michael E, Faull Kym, Memarzadeh Sanaz Low levels of circulating estrogen sensitize PTEN-null endometrial tumors to PARP inhibition in vivo. Molecular cancer therapeutics
. 2013; 12(12): 2917-28.
Drake Justin M, Graham Nicholas A, Lee John K, Stoyanova Tanya, Faltermeier Claire M, Sud Sudha, Titz BjÃ¶rn, Huang Jiaoti, Pienta Kenneth J, Graeber Thomas G, Witte Owen N Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets. Proceedings of the National Academy of Sciences of the United States of America
. 2013; 110(49): E4762-9.
Stoyanova Tanya, Cooper Aaron R, Drake Justin M, Liu Xian, Armstrong Andrew J, Pienta Kenneth J, Zhang Hong, Kohn Donald B, Huang Jiaoti, Witte Owen N, Goldstein Andrew S Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells. Proceedings of the National Academy of Sciences of the United States of America
. 2013; 110(50): 20111-6.
Smith Daniel A, Kiba Atsushi, Zong Yang, Witte Owen N Interleukin-6 and oncostatin-M synergize with the PI3K/AKT pathway to promote aggressive prostate malignancy in mouse and human tissues. Molecular cancer research : MCR
. 2013; 11(10): 1159-65.
Schjerven Hilde, McLaughlin Jami, Arenzana Teresita L, Frietze Seth, Cheng Donghui, Wadsworth Sarah E, Lawson Gregory W, Bensinger Steven J, Farnham Peggy J, Witte Owen N, Smale Stephen T Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nature immunology
. 2013; 14(10): 1073-83.
Janzen Deanna M, Rosales Miguel A, Paik Daniel Y, Lee Daniel S, Smith Daniel A, Witte Owen N, Iruela-Arispe M Luisa, Memarzadeh Sanaz Progesterone receptor signaling in the microenvironment of endometrial cancer influences its response to hormonal therapy. Cancer research
. 2013; 73(15): 4697-710.
Zangle Thomas A, Burnes Daina, Mathis Colleen, Witte Owen N, Teitell Michael A Quantifying biomass changes of single CD8+ T cells during antigen specific cytotoxicity. PloS one
. 2013; 8(7): e68916.
Goldstein Andrew S, Witte Owen N Does the microenvironment influence the cell types of origin for prostate cancer?. Genes & development
. 2013; 27(14): 1539-44.
Giannoni Francesca, Hardee Cinnamon L, Wherley Jennifer, Gschweng Eric, Senadheera Shantha, Kaufman Michael L, Chan Rebecca, Bahner Ingrid, Gersuk Vivian, Wang Xiaoyan, Gjertson David, Baltimore David, Witte Owen N, Economou James S, Ribas Antoni, Kohn Donald B Allelic Exclusion and Peripheral Reconstitution by TCR Transgenic T Cells Arising From Transduced Human Hematopoietic Stem/Progenitor Cells. Molecular therapy : the journal of the American Society of Gene Therapy
. 2013; 21(5): 1044-54.
Ma Chao, Cheung Ann F, Chodon Thinle, Koya Richard C, Wu Zhongqi, Ng Charles, Avramis Earl, Cochran Alistair J, Witte Owen N, Baltimore David, Chmielowski Bartosz, Economou James S, Comin-Anduix Begonya, Ribas Antoni, Heath James R Multifunctional T-cell analyses to study response and progression in adoptive cell transfer immunotherapy. Cancer discovery
. 2013; 3(4): 418-29.
McCracken Melissa N, Gschweng Eric H, Nair-Gill Evan, McLaughlin Jami, Cooper Aaron R, Riedinger Mireille, Cheng Donghui, Nosala Christopher, Kohn Donald B, Witte Owen N Long-term in vivo monitoring of mouse and human hematopoietic stem cell engraftment with a human positron emission tomography reporter gene. Proceedings of the National Academy of Sciences of the United States of America
. 2013; 110(5): 1857-62.
Goldstein Andrew S, Witte Owen N A plethora of progenitors in the post-natal prostate. EMBO reports
. 2012; 13(12): 1036-7.
Braas Daniel, Ahler Ethan, Tam Brenna, Nathanson David, Riedinger Mirielle, Benz Matthias R, Smith Kathleen B, Eilber Fritz C, Witte Owen N, Tap William D, Wu Hong, Christofk Heather R Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment. Cancer discovery
. 2012; 2(12): 1109-17.
Austin Wayne R, Armijo Amanda L, Campbell Dean O, Singh Arun S, Hsieh Terry, Nathanson David, Herschman Harvey R, Phelps Michael E, Witte Owen N, Czernin Johannes, Radu Caius G Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress. The Journal of experimental medicine
. 2012; 209(12): 2215-28.
Paik Daniel Y, Janzen Deanna M, Schafenacker Amanda M, Velasco Victor S, Shung May S, Cheng Donghui, Huang Jiaoti, Witte Owen N, Memarzadeh Sanaz Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation. Stem cells (Dayton, Ohio)
. 2012; 30(11): 2487-97.
Stoyanova Tanya, Goldstein Andrew S, Cai Houjian, Drake Justin M, Huang Jiaoti, Witte Owen N Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via Î²-catenin signaling. Genes & development
. 2012; 26(20): 2271-85.
Cai Houjian, Memarzadeh Sanaz, Stoyanova Tanya, Beharry Zanna, Kraft Andrew S, Witte Owen N Collaboration of Kras and androgen receptor signaling stimulates EZH2 expression and tumor-propagating cells in prostate cancer. Cancer research
. 2012; 72(18): 4672-81.
Tsukada Satoshi, Saffran Douglas C, Rawlings David J, Parolini Ornella, Allen R Cutler, Klisak Ivana, Sparkes Robert S, Kubagawa Hiromi, Mohandas Thuluvancheri, Quan Shirley, Belmont John W, Cooper Max D, Conley Mary Ellen, Witte Owen N Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. 1993. Journal of immunology (Baltimore, Md. : 1950)
. 2012; 188(7): 2936-47.
Janzen Deanna M, Cheng Donghui, Schafenacker Amanda M, Paik Daniel Y, Goldstein Andrew S, Witte Owen N, Jaroszewicz Artur, Pellegrini Matteo, Memarzadeh Sanaz Estrogen and progesterone together expand murine endometrial epithelial progenitor cells. Stem cells (Dayton, Ohio)
. 2012; 31(4): 808-22.
Jiao Jing, Hindoyan Antreas, Wang Shunyou, Tran Linh M, Goldstein Andrew S, Lawson Devon, Chen Donghui, Li Yunfeng, Guo Changyong, Zhang Baohui, Fazli Ladan, Gleave Martin, Witte Owen N, Garraway Isla P, Wu Hong Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells. PloS one
. 2012; 7(8): e42564.
Drake Justin M, Graham Nicholas A, Stoyanova Tanya, Sedghi Amir, Goldstein Andrew S, Cai Houjian, Smith Daniel A, Zhang Hong, Komisopoulou Evangelia, Huang Jiaoti, Graeber Thomas G, Witte Owen N Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression.Proceedings of the National Academy of Sciences of the United States of America
. 2012; 109(5): 1643-1648.
Chen Aishe, Dong Lixue, Leffler Nancy R, Asch Adam S, Witte Owen N, Yang Li V Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway. PloS one
. 2011; 6(11): e27586.
Goldstein Andrew S, Drake Justin M, Burnes Daina L, Finley David S, Zhang Hong, Reiter Robert E, Huang Jiaoti, Witte Owen N Purification and direct transformation of epithelial progenitor cells from primary human prostate. Nature protocols
. 2011; 6(5): 656-67.
Memarzadeh Sanaz, Cai Houjian, Janzen Deanna M, Xin Li, Lukacs Rita, Riedinger Mireille, Zong Yang, DeGendt Karel, Verhoeven Guido, Huang Jiaoti, Witte Owen N Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal. Proceedings of the National Academy of Sciences of the United States of America
. 2011; 108(19): 7962-7.
Schwarzenberg Johannes, Radu Caius G, Benz Matthias, Fueger Barbara, Tran Andrew Q, Phelps Michael E, Witte Owen N, Satyamurthy Nagichettiar, Czernin Johannes, Schiepers Christiaan Human biodistribution and radiation dosimetry of novel PET probes targeting the deoxyribonucleoside salvage pathway. European journal of nuclear medicine and molecular imaging
. 2011; 38(4): 711-21.
Goldstein Andrew S, Zong Yang, Witte Owen N A two-step toward personalized therapies for prostate cancer. Science translational medicine
. 2011; 3(72): 72ps7.
Cai Houjian, Babic Ivan, Wei Xiao, Huang Jiaoti, Witte Owen N Invasive prostate carcinoma driven by c-Src and androgen receptor synergy. Cancer research
. 2011; 71(3): 862-72.
Wu Ting-Hsiang, Teslaa Tara, Kalim Sheraz, French Christopher T, Moghadam Shahriar, Wall Randolph, Miller Jeffery F, Witte Owen N, Teitell Michael A, Chiou Pei-Yu Photothermal nanoblade for large cargo delivery into mammalian cells. Analytical chemistry
. 2011; 83(4): 1321-7.
Huang Xinqiang, Gschweng Eric, Van Handel Ben, Cheng Donghui, Mikkola Hanna K A, Witte Owen N Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells. Blood
. 2011; 117(7): 2157-65.
Tsutsui Hideaki, Valamehr Bahram, Hindoyan Antreas, Qiao Rong, Ding Xianting, Guo Shuling, Witte Owen N, Liu Xin, Ho Chih-Ming, Wu Hong An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells. Nature communications
. 2011; 2(3): 167.
Lukacs Rita U, Memarzadeh Sanaz, Wu Hong, Witte Owen N Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation. Cell stem cell
. 2010; 7(6): 682-93.
Signer Robert A J, Montecino-Rodriguez Encarnacion, Witte Owen N, Dorshkind Kenneth Immature B-cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia. Blood
. 2010; 116(14): 2522-30.
Goldstein Andrew S, Stoyanova Tanya, Witte Owen N Primitive origins of prostate cancer: in vivo evidence for prostate-regenerating cells and prostate cancer-initiating cells. Molecular oncology
. 2010; 4(5): 385-96.
Goldstein Andrew S, Huang Jiaoti, Guo Changyong, Garraway Isla P, Witte Owen N Identification of a cell of origin for human prostate cancer. Science (New York, N.Y.)
. 2010; 329(5991): 568-71.
Shu Chengyi J, Campbell Dean O, Lee Jason T, Tran Andrew Q, Wengrod Jordan C, Witte Owen N, Phelps Michael E, Satyamurthy Nagichettiar, Czernin Johannes, Radu Caius G Novel PET probes specific for deoxycytidine kinase. Journal of nuclear medicine : official publication, Society of Nuclear Medicine
. 2010; 51(7): 1092-8.
Nair-Gill Evan, Wiltzius Stephanie M, Wei Xiao X, Cheng Donghui, Riedinger Mireille, Radu Caius G, Witte Owen N PET probes for distinct metabolic pathways have different cell specificities during immune responses in mice. The Journal of clinical investigation
. 2010; 120(6): 2005-15.
Kamei Ken-ichiro, Ohashi Minori, Gschweng Eric, Ho Quinn, Suh Jane, Tang Jinghua, For Yu Zeta Tak, Clark Amander T, Pyle April D, Teitell Michael A, Lee Ki-Bum, Witte Owen N, Tseng Hsian-Rong Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions. Lab on a chip
. 2010; 10(9): 1113-9.
Brewer Sarah, Nair-Gill Evan, Wei Bo, Chen Ling, Li Xiaoxiao, Riedinger Mireille, Campbell Dean O, Wiltzius Stephanie, Satyamurthy Nagichettiar, Phelps Michael E, Radu Caius, Witte Owen N, Braun Jonathan Epithelial uptake of [18F]1-(2′-deoxy-2′-arabinofuranosyl) cytosine indicates intestinal inflammation in mice. Gastroenterology
. 2010; 138(4): 1266-75.
Garraway Isla P, Sun Wenyi, Tran Chau P, Perner Sven, Zhang Bao, Goldstein Andrew S, Hahm Scott A, Haider Maahum, Head Christian S, Reiter Robert E, Rubin Mark A, Witte Owen N Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo. The Prostate
. 2010; 70(5): 491-501.
Baltimore David, Witte Owen N, Yang Lili, Economou James, Ribas Antoni Overcoming barriers to programming a therapeutic cellular immune response to fight melanoma. Pigment cell & melanoma research
. 2010; 23(2): 288-9.
Toy Gerald, Austin Wayne R, Liao Hsiang-I, Cheng Donghui, Singh Arun, Campbell Dean O, Ishikawa Tomo-o, Lehmann Lynn W, Satyamurthy Nagichettiar, Phelps Michael E, Herschman Harvey R, Czernin Johannes, Witte Owen N, Radu Caius G Requirement for deoxycytidine kinase in T and B lymphocyte development. Proceedings of the National Academy of Sciences of the United States of America
. 2010; 107(12): 5551-6.
Mikkola Hanna K A, Radu Caius G, Witte Owen N Targeting leukemia stem cells. Nature biotechnology
. 2010; 28(3): 237-8.
Laing Rachel E, Nair-Gill Evan, Witte Owen N, Radu Caius G Visualizing cancer and immune cell function with metabolic positron emission tomography.Current opinion in genetics & development
. 2010; 20(1): 100-5.
Lukacs Rita U, Goldstein Andrew S, Lawson Devon A, Cheng Donghui, Witte Owen N Isolation, cultivation and characterization of adult murine prostate stem cells. Nature protocols
. 2010; 5(4): 702-13.
Mulholland David J, Xin Li, Morim Ashkan, Lawson Devon, Witte Owen, Wu Hong Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. Cancer research
. 2009; 69(22): 8555-62.
Kottyan Leah C, Collier Ann R, Cao Khanh H, Niese Kathryn A, Hedgebeth Megan, Radu Caius G, Witte Owen N, Khurana Hershey Gurjit K, Rothenberg Marc E, Zimmermann Nives Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner. Blood
. 2009; 114(13): 2774-82.
Kwong Gabriel A, Radu Caius G, Hwang Kiwook, Shu Chengyi J, Ma Chao, Koya Richard C, Comin-Anduix Begonya, Hadrup Sine Reker, Bailey Ryan C, Witte Owen N, Schumacher Ton N, Ribas Antoni, Heath James R Modular nucleic acid assembled p/MHC microarrays for multiplexed sorting of antigen-specific T cells. Journal of the American Chemical Society
. 2009; 131(28): 9695-703.
Yu Zeta Tak For, Kamei Ken-ichiro, Takahashi Hiroko, Shu Chengyi Jenny, Wang Xiaopu, He George Wenfu, Silverman Robert, Radu Caius G, Witte Owen N, Lee Ki-Bum, Tseng Hsian-Rong Integrated microfluidic devices for combinatorial cell-based assays. Biomedical microdevices
. 2009; 11(3): 547-55.
Kamei Ken-Ichiro, Guo Shuling, Yu Zeta Tak For, Takahashi Hiroko, Gschweng Eric, Suh Carol, Wang Xiaopu, Tang Jinghua, McLaughlin Jami, Witte Owen N, Lee Ki-Bum, Tseng Hsian-Rong An integrated microfluidic culture device for quantitative analysis of human embryonic stem cells. Lab on a chip
. 2009; 9(4): 555-63.
Shu Chengyi J, Radu Caius G, Shelly Stephanie M, Vo Dan D, Prins Robert, Ribas Antoni, Phelps Michael E, Witte Owen N Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen. International immunology
. 2009; 21(2): 155-65.
Signer Robert A J, Montecino-Rodriguez Encarnacion, Witte Owen N, Dorshkind Kenneth Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf. Genes & development
. 2008; 22(22): 3115-20.
Prins Robert M, Shu Chengyi J, Radu Caius G, Vo Dan D, Khan-Farooqi Haumith, Soto Horacio, Yang Meng-Yin, Lin Muh-Shi, Shelly Stephanie, Witte Owen N, Ribas Antoni, Liau Linda M Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain. Cancer immunology, immunotherapy : CII
. 2008; 57(9): 1279-89.
Valamehr Bahram, Jonas Steven J, Polleux Julien, Qiao Rong, Guo Shuling, Gschweng Eric H, Stiles Bangyan, Kam Korey, Luo Tzy-Jiun M, Witte Owen N, Liu Xin, Dunn Bruce, Wu Hong Hydrophobic surfaces for enhanced differentiation of embryonic stem cell-derived embryoid bodies. Proceedings of the National Academy of Sciences of the United States of America
. 2008; 105(38): 14459-64.
Radu Caius G, Shu Chengyi J, Nair-Gill Evan, Shelly Stephanie M, Barrio Jorge R, Satyamurthy Nagichettiar, Phelps Michael E, Witte Owen N Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [18F]-labeled 2′-deoxycytidine analog. Nature medicine
. 2008; 14(7): 783-8.
Lo Roger S, Witte Owen N Transforming growth factor-beta activation promotes genetic context-dependent invasion of immortalized melanocytes. Cancer research
. 2008; 68(11): 4248-57.
Moore Miranda L, Teitell Michael A, Kim Yoon, Watabe Tetsuro, Reiter Robert E, Witte Owen N, Dubey Purnima Deletion of PSCA increases metastasis of TRAMP-induced prostate tumors without altering primary tumor formation. The Prostate
. 2008; 68(2): 139-51.
Peter Christoph, Waibel Michaela, Radu Caius G, Yang Li V, Witte Owen N, Schulze-Osthoff Klaus, Wesselborg Sebastian, Lauber Kirsten Migration to apoptotic “find-me” signals is mediated via the phagocyte receptor G2A. The Journal of biological chemistry
. 2008; 283(9): 5296-305.
Nair-Gill Evan D, Shu Chengyi J, Radu Caius G, Witte Owen N Non-invasive imaging of adaptive immunity using positron emission tomography.Immunological reviews
. 2008; 221(9): 214-28.
Memarzadeh Sanaz, Xin Li, Mulholland David J, Mansukhani Alka, Wu Hong, Teitell Michael A, Witte Owen N Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor. Cancer cell
. 2007; 12(6): 572-85.
Xin Li, Lukacs Rita U, Lawson Devon A, Cheng Donghui, Witte Owen N Self-renewal and multilineage differentiation in vitro from murine prostate stem cells.Stem cells (Dayton, Ohio)
. 2007; 25(11): 2760-9.
Signer Robert A J, Montecino-Rodriguez Encarnacion, Witte Owen N, McLaughlin Jami, Dorshkind Kenneth Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia. Blood
. 2007; 110(6): 1831-9.
Dorshkind Kenneth, Witte Owen N Linking the hematopoietic microenvironment to imatinib-resistant Ph+ B-ALL. Genes & development
. 2007; 21(18): 2249-52.
Bailey Ryan C, Kwong Gabriel A, Radu Caius G, Witte Owen N, Heath James R DNA-encoded antibody libraries: a unified platform for multiplexed cell sorting and detection of genes and proteins. Journal of the American Chemical Society
. 2007; 129(7): 1959-67.
Yang Li V, Radu Caius G, Roy Meenakshi, Lee Sunyoung, McLaughlin Jami, Teitell Michael A, Iruela-Arispe M Luisa, Witte Owen N Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor. Molecular and cellular biology
. 2007; 27(4): 1334-47.
Lei Qunying, Jiao Jing, Xin Li, Chang Chun-Ju, Wang Shunyou, Gao Jing, Gleave Martin E, Witte Owen N, Liu Xin, Wu Hong NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss. Cancer cell
. 2006; 9(5): 367-78.
Khan Abdul Q, Sen Goutam, Guo Shuling, Witte Owen N, Snapper Clifford M Induction of in vivo antipolysaccharide immunoglobulin responses to intact Streptococcus pneumoniae is more heavily dependent on Btk-mediated B-cell receptor signaling than antiprotein responses. Infection and immunity
. 2006; 74(2): 1419-24.
Guo Shuling, Wahl Matthew I, Witte Owen N Mutational analysis of the SH2-kinase linker region of Bruton’s tyrosine kinase defines alternative modes of regulation for cytoplasmic tyrosine kinase families. International immunology
. 2006; 18(1): 79-87.
Radu Caius G, Cheng Donghui, Nijagal Amar, Riedinger Mireille, McLaughlin Jami, Yang Li V, Johnson James, Witte Owen N Normal immune development and glucocorticoid-induced thymocyte apoptosis in mice deficient for the T-cell death-associated gene 8 receptor. Molecular and cellular biology
. 2006; 26(2): 668-77.
Lee Chung-Cheng, Sui Guodong, Elizarov Arkadij, Shu Chengyi Jenny, Shin Young-Shik, Dooley Alek N, Huang Jiang, Daridon Antoine, Wyatt Paul, Stout David, Kolb Hartmuth C, Witte Owen N, Satyamurthy Nagichettiar, Heath James R, Phelps Michael E, Quake Stephen R, Tseng Hsian-Rong Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics. Science (New York, N.Y.)
. 2005; 310(5755): 1793-6.
Wang Li, Radu Caius G, Yang Li V, Bentolila Laurent A, Riedinger Mireille, Witte Owen N Lysophosphatidylcholine-induced surface redistribution regulates signaling of the murine G protein-coupled receptor G2A. Molecular biology of the cell
. 2005; 16(5): 2234-47.
Beillard Emmanuel, Witte Owen N Unraveling kinase signaling pathways with chemical genetic and chemical proteomic approaches. Cell cycle (Georgetown, Tex.)
. 2005; 4(3): 434-7.
Yang Li V, Radu Caius G, Wang Li, Riedinger Mireille, Witte Owen N Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A. Blood
. 2005; 105(3): 1127-34.
Yu Phyllis W, Tabuchi Ruby S, Kato Roberta M, Astrakhan Alexander, Humblet-Baron Stephanie, Kipp Kevin, Chae Keun, Ellmeier Wilfried, Witte Owen N, Rawlings David J Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer. Blood
. 2004; 104(5): 1281-90.
Kharas Michael G, Deane Jonathan A, Wong Stephane, O’Bosky Karen R, Rosenberg Naomi, Witte Owen N, Fruman David A Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells. Blood
. 2004; 103(11): 4268-75.
Dorshkind Kenneth, Witte Owen Got MLL? Definitive hematopoiesis requires MLL gene expression. Molecular cell
. 2004; 13(6): 765-6.
Whyburn Lindsey R, Halcomb Kristina E, Contreras Cristina M, Lowell Clifford A, Witte Owen N, Satterthwaite Anne B Reduced dosage of Bruton’s tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in lyn-/- mice. Journal of immunology (Baltimore, Md. : 1950)
. 2003; 171(4): 1850-8.
Wong Stephane, McLaughlin Jami, Cheng Donghui, Witte Owen N Cell context-specific effects of the BCR-ABL oncogene monitored in hematopoietic progenitors. Blood
. 2003; 101(10): 4088-97.
Whyburn Lindsey R, Halcomb Kristina E, Contreras Cristina M, Pappu Rajita, Witte Owen N, Chan Andrew C, Satterthwaite Anne B Haploinsufficiency of B cell linker protein enhances B cell signaling defects in mice expressing a limiting dosage of Bruton’s tyrosine kinase. International immunology
. 2003; 15(3): 383-92.
Kabarowski Janusz H S, Xu Yan, Witte Owen N Lysophosphatidylcholine as a ligand for immunoregulation. Biochemical pharmacology
. 2002; 64(2): 161-7.
Fujimoto Manabu, Poe Jonathan C, Satterthwaite Anne B, Wahl Matthew I, Witte Owen N, Tedder Thomas F Complementary roles for CD19 and Bruton’s tyrosine kinase in B lymphocyte signal transduction. Journal of immunology (Baltimore, Md. : 1950)
. 2002; 168(11): 5465-76.
Le Lu Q, Kabarowski Janusz H S, Wong Stephane, Nguyen Khoi, Gambhir Sanjiv S, Witte Owen N Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene. Cancer cell
. 2002; 1(4): 381-91.