Lili Yang, Ph.D.
Our overall interest is to decipher the molecular mechanisms responsible for productive or defective immune responses against chronic diseases like cancer and exploit knowledge to design effective therapeutic strategies with potential clinical applications.
Smith DJ., Lin LJ., Moom H., Pham AT., Wang X., Liu S., Ji S., Rezek V., Shimizu S., Ruiz M., Lam J., Janzen DM., Memarzadeh S., Kohn DB., Zack JA., Kitchen SG., An DS., Yang L. Propagating Humanized BLT Mice for the Study of Human Immunology and Immunotherapy. Stem Cells Dev. September 2016, ahead of print. [ Link ]
Smith DJ., Liu S., Ji S., Li B., McLaughlin J., Cheng D., Witte ON. and Yang L. Genetic Engineering of Hematopoietic Stem Cells to Generate Invariant Natural Killer T Cells. Proc. Natl. Acad. Sci. USA 2015, 112(5):1523-28. [ Link ]
Chodon T., Comin-Anduix B., Chmielowski B., Koya R.C., Wu Z., Auerbach M., Ng C., Avramis E., Seja E., Villanueva A., McCannel T.A., Ishiyama A., Czernin J., Radu C.G., Wang X., Gjertson D.W., Cochran A.J., Cornetta K., Wong D.J.L., Kaplan-Lefko P., Hamid O., Samlowski W., Cohen P.A., Daniels G.A., Mukherji B., Yang L., Zack J.A., Kohn D.B., Heath J.R., Glaspy J.A., Witte O.N., Baltimore D., Economou J.S. and Ribas. Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma. Clin. Cancer Res. 2014, 20(9):2457-65. [ Link ]
Yang L, Wang P. Passive immunization against HIV/AIDS by antibody gene transfer. Viruses. 2014, 6(2):428-47. [ Link ]
Yu KK, Aguilar K, Tsai J, Galimidi R, Gnanapragasam P, Yang L, Baltimore D.
Use of mutated self-cleaving 2A peptides as a molecular rheostat to direct simultaneous formation of membrane and secreted anti-HIV immunoglobulins. PLoS One. 2012, 7(11):e50438. [ Link ]
Yang L., Boldin M.P., Yu Y., Liu C.S., Ea C.K., Taganov K.D., Zhao J.L. and Baltimore D. MicroRNA-146a control of the resolution of T cell responses in mice. J Exp Med. 2012, 209(9):1655-70. [ Link ]
Hur E.M., Patel S.N., Shimizu S., Rao D., Gnanapragasam P.N.P., An D.S., Yang L. and Baltimore D. Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice. Blood. 2012, 120(23):4571-82. [ Link ]
Xiao L., Kim J., Lim M., Dai B., Yang L., Reed S., Baltimore D. and Wang P. A TLR4 agonist synergizes with dendritic cell-directed lentiviral vectors for inducing antigen-specific immune responses. Vaccine. 2012, 30(15):2570-81. [ Link ]
Balazs AB, Chen J, Hong CM, Rao DS, Yang L, Baltimore D. Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature. 2011, 481(7379):81-4. [ Link ]
Yang L, Yu Y, Kalwani M, Tseng TW, Baltimore D. Homeostatic cytokines orchestrate the segregation of CD4 and CD8 memory T-cell reservoirs in mice. Blood. 2011, 118(11):3039-50. [ Link ]
Boldin MP, Taganov KD, Rao DS, Yang L, Zhao JL, Kalwani M, Garcia-Flores Y, Luong M, Devrekanli A, Xu J, Sun G, Tay J, Linsley PS, Baltimore D. miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. J Exp Med. 2011, 208(6):1189-201. [ Link ]
Luo XM, Lei MY, Feidi RA, West AP Jr, Balazs AB, Bjorkman PJ, Yang L, Baltimore D. Dimeric 2G12 as a potent protection against HIV-1. PLoS Pathog. 2010, 6(12):e1001225. [ Link ]
O’Connell RM, Balazs AB, Rao DS, Kivork C, Yang L, Baltimore D. Lentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populations. PLoS One. 2010, 5(8):e12009. [ Link ]
Baltimore D, Witte ON, Yang L, Economou J, Ribas A. Overcoming barriers to programming a therapeutic cellular immune response to fight melanoma.
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Dai B, Yang L, Yang H, Hu B, Baltimore D, Wang P. HIV-1 Gag-specific immunity induced by a lentivector-based vaccine directed to dendritic cells. Proc Natl Acad Sci USA 2009, 106(48):20382-7. [ Link ]
Luo XM, Maarschalk E, O’Connell RM, Wang P, Yang L, Baltimore D. Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes. Blood. 2009, 113(7):1422-31. [ Link ]
Chhabra A, Yang L, Wang P, Comin-Anduix B, Das R, Chakraborty NG, Ray S, Mehrotra S, Yang H, Hardee CL, Hollis R, Dorsky DI, Koya R, Kohn DB, Ribas A, Economou JS, Baltimore D, Mukherji B. CD4+CD25- T cells transduced to express MHC class I-restricted epitope-specific TCR synthesize Th1 cytokines and exhibit MHC class I-restricted cytolytic effector function in a human melanoma model. J Immunol. 2008, 181(2):1063-70. [ Link ]
Ziegler L, Yang L, Joo Ki, Yang H, Baltimore D, Wang P. Targeting lentiviral vectors to antigen-specific immunoglobulins. Hum Gene Ther. 2008, 19(9):861-72. [ Link ]
Yang L, Yang H, Rideout K, Cho T, Joo KI, Ziegler L, Elliot A, Walls A, Yu D, Baltimore D, Wang P. Engineered lentivector targeting of dendritic cells for in vivo immunization. Nat Biotechnol. 2008, 26(3):326-34. [ Link ]
Yang L, Bailey L, Baltimore D, Wang P. Targeting lentiviral vectors to specific cell types in vivo. Proc Natl Acad Sci USA. 2006, 103(31):11479-84. [ Link ]
Yang L, Baltimore D. Long-term in vivo provision of antigen-specific T cell immunity by programming hematopoietic stem cells. Proc Natl Acad Sci USA. 2005, 102(12):4518-23-34. [ Link ]
Yang L, Qin XF, Baltimore D, Van Parijs L. Generation of functional antigen-specific T cells in defined genetic backgrounds by retrovirus-mediated expression of TCR cDNAs in hematopoietic precursor cells. Proc Natl Acad Sci USA. 2002, 99(9):6204-9. [ Link ]
Yang L, Kuo CB, Liu Y, Coss D, Xu X, Chen C, Oster-Granite ML, Walker AM. Administration of unmodified prolactin (U-PRL) and a molecular mimic of phosphorylated prolactin (PP-PRL) during rat pregnancy provides evidence that the U-PRL:PP-PRL ratio is crucial to the normal development of pup tissues. J Endocrinol. 2001, 168(2):227-38. [ Link ]
Bridges R, Rigero B, Byrnes E, Yang L, Walker A. Central infusions of the recombinant human prolactin receptor antagonist, S179D-PRL, delay the onset of maternal behavior in steroid-primed, nulliparous female rats. [ Link ]
Coss D, Yang L, Kuo CB, Xu X, Luben RA, Walker AM. Effects of prolactin on osteoblast alkaline phosphatase and bone formation in the developing rat.
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Coss D, Kuo CB, Yang L, Ingleton P, Luben R, Walker AM. Dissociation of Janus kinase 2 and signal transducer and activator of transcription 5 activation after treatment of Nb2 cells with a molecular mimic of phosphorylated prolactin.
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