Selected Publications


The following are the most recent and some selected publications from our laboratory. For other publications please click here. For reprints please contact Dr. Zack.

Primary research articles

HIV restriction in quiescent CD4⁺ T cells.

Zack JA, Kim SG, Vatakis DN.

Retrovirology. 2013 Apr 4;10:37. doi: 10.1186/1742-4690-10-37. Free PMC Article

Introduction of exogenous T-cell receptors into human hematopoietic progenitors results in exclusion of endogenous T-cell receptor expression.

Vatakis DN, Arumugam B, Kim SG, Bristol G, Yang O, Zack JA.

Mol Ther. 2013 May;21(5):1055-63.

Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol.

Liu SY, Aliyari R, Chikere K, Li G, Marsden MD, Smith JK, Pernet O, Guo H, Nusbaum R, Zack JA, Freiberg AN, Su L, Lee B, Cheng G.

Immunity. 2013 Jan 24;38(1):92-105.

Using the BLT humanized mouse as a stem cell based gene therapy tumor model.

Vatakis DN, Bristol GC, Kim SG, Levin B, Liu W, Radu CG, Kitchen SG, Zack JA.

J Vis Exp. 2012 Dec 18;(70):e4181.

Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro.

DeChristopher BA, Loy BA, Marsden MD, Schrier AJ, Zack JA, Wender PA.

Nat Chem. 2012 Sep;4(9):705-10. Free PMC Article

In Vivo Suppression of HIV by Antigen Specific T Cells Derived from Engineered Hematopoietic Stem Cells.

Scott G. Kitchen, Bernard R. Levin, Gregory Bristol,Valerie Rezek, Sohn Kim, Christian Aguilera-Sandoval, Arumugam Balamurugan, Otto O. Yang, Jerome A. Zack

PLoS Pathog. 2012 Apr;8(4):e1002649. Epub 2012 Apr 12.

HIV latency in the humanized BLT mouse.

Marsden MD, Kovochich M, Suree N, Shimizu S, Mehta R, Cortado R, Bristol G, An DS, Zack JA.

J Virol. 2012 Jan;86(1):339-47. Epub 2011 Nov 9.(PDF)

Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells.

Vatakis DN, Koya RC, Nixon CC, Wei L, Kim SG, Avancena P, Bristol G, Baltimore D, Kohn DB, Ribas A, Radu CG, Galic Z, Zack JA.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):E1408-16. Epub 2011 Nov 28.(PDF)

HIV latency is influenced by regions of the viral genome outside of the long terminal repeats and regulatory genes

Marsden MD, Burke BP, Zack JA.

Virology. 2011 Sep 1;417(2):394-9. Epub 2011 Jul 20.

Phase I/II Clinical Trials Using Gene-Modified Adult Hematopoietic Stem Cells for HIV: Lessons Learnt.

Mitsuyasu RT, Zack JA, Macpherson JL, Symonds GP.

Stem Cells Int. 2011;2011:393698. Epub 2011 Jun 13. (PDF)

Single mutations in HIV integrase confer high-level resistance to raltegravir in primary human macrophages.

Marsden MD, Avancena P, Kitchen CM, Hubbard T, Zack JA.

Antimicrob Agents Chemother. 2011 Aug;55(8):3696-702. Epub 2011 May 31. (PDF)

Activation of latent HIV using drug-loaded nanoparticles.

Kovochich M, Marsden MD, Zack JA.

PLoS One. 2011 Apr 5;6(4):e18270(PDF)

A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model.

Shimizu S, Hong P, Arumugam B, Pokomo L, Boyer J, Koizumi N, Kittipongdaja P, Chen A, Bristol G, Galic Z, Zack JA, Yang O, Chen IS, Lee B, An DS.

Blood. 2010 Feb 25;115(8):1534-44. Epub 2009 Dec 17. (PDF)

Engineering antigen-specific T cells from genetically modified human hematopoietic stem cells in immunodeficient mice.

Kitchen SG, Bennett M, Galić Z, Kim J, Xu Q, Young A, Lieberman A, Joseph A, Goldstein H, Ng H, Yang O, Zack JA.

PLoS One. 2009 Dec 7;4(12):e8208. (PDF)

Human immunodeficiency virus integration efficiency and site selection in quiescent CD4+ T cells.

Vatakis DN, Kim S, Kim N, Chow SA, Zack JA.

J Virol. 2009 Jun;83(12):6222-33. Epub 2009 Apr 15 (pdf)

Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells.

Mitsuyasu RT, Merigan TC, Carr A, Zack JA, Winters MA, Workman C, Bloch M, Lalezari J, Becker S, Thornton L, Akil B, Khanlou H, Finlayson R, McFarlane R, Smith DE, Garsia R, Ma D, Law M, Murray JM, von Kalle C, Ely JA, Patino SM, Knop AE, Wong P, Todd AV, Haughton M, Fuery C, Macpherson JL, Symonds GP, Evans LA, Pond SM, Cooper DA.

Nat Med. 2009 Mar;15(3):285-92. Epub 2009 Feb 15. (PDF)

Differentially stimulated CD4+ T cells display altered human immunodeficiency virus infection kinetics: implications for the efficacy of antiviral agents.

Vatakis DN, Nixon CC, Bristol G, Zack JA.

J Virol. 2009 Apr;83(7):3374-8. Epub 2009 Jan 7. (PDF)

Macrophage differentiation from embryoid bodies derived from human embryonic stem cells.

Subramanian A, Guo B, Marsden MD, Galic Z, Kitchen S, Kacena A, Brown HJ, Cheng G, Zack JA.

J Stem Cells. 2009;4(1):29-45. doi: jsc.2009.4.1.29.

Short communication: Activating stimuli enhance immunotoxin-mediated killing of HIV-infected macrophages.

Marsden MD, Xu J, Hamer D, Zack JA.

AIDS Res Hum Retroviruses. 2008 Nov;24(11):1399-404.(PDF)

Generation of T lineage cells from human embryonic stem cells in a feeder free system.

Galić Z, Kitchen SG, Subramanian A, Bristol G, Marsden MD, Balamurugan A, Kacena A, Yang O, Zack JA.

Stem Cells. 2009 Jan;27(1):100-7.(PDF)

Primary cell model for activation-inducible human immunodeficiency virus.

Burke B, Brown HJ, Marsden MD, Bristol G, Vatakis DN, Zack JA.

J Virol. 2007 Jul;81(14):7424-34. Epub 2007 May 2.(PDF)

Human immunodeficiency virus bearing a disrupted central DNA flap is pathogenic in vivo.

Marsden MD, Zack JA.

J Virol. 2007 Jun;81(11):6146-50.(PDF)

Immediate activation fails to rescue efficient human immunodeficiency virus replication in quiescent CD4+ T cells.

Vatakis DN, Bristol G, Wilkinson TA, Chow SA, Zack JA.

J Virol. 2007 Apr;81(7):3574-82. Epub 2007 Jan 17.(PDF)

CD4 expression on activated NK cells: ligation of CD4 induces cytokine expression and cell migration.

Bernstein HB, Plasterer MC, Schiff SE, Kitchen CM, Kitchen S, Zack JA.

J Immunol. 2006 Sep 15;177(6):3669-76.(PDF)

T lineage differentiation from human embryonic stem cells.

Galic Z, Kitchen SG, Kacena A, Subramanian A, Burke B, Cortado R, Zack JA.

Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11742-7.(PDF)

Rapid expression of human immunodeficiency virus following activation of latently infected cells.

Arlen PA, Brooks DG, Gao LY, Vatakis D, Brown HJ, Zack JA.

J Virol. 2006 Feb;80(3):1599-603.(PDF)

The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens.

Kitchen SG, Whitmire JK, Jones NR, Galic Z, Kitchen CM, Ahmed R, Zack JA.

Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3794-9. Epub 2005 Feb 24.(PDF)

Expression-based monitoring of transcription factor activity: the TELiS database.

Cole SW, Yan W, Galic Z, Arevalo J, Zack JA.

Bioinformatics. 2005 Mar;21(6):803-10. (PDF)

CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection.

Kitchen SG, Jones NR, LaForge S, Whitmire JK, Vu BA, Galic Z, Brooks DG, Brown SJ, Kitchen CM, Zack JA.

Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8727-32.(PDF)

Identification of T cell-signaling pathways that stimulate latent HIV in primary cells.

Brooks DG, Arlen PA, Gao L, Kitchen CM, Zack JA.

Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12955-60.(PDF)

Molecular characterization, reactivation, and depletion of latent HIV.

Brooks DG, Hamer DH, Arlen PA, Gao L, Bristol G, Kitchen CM, Berger EA, Zack JA.

Immunity. 2003 Sep;19(3):413-23.(PDF)

Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype.

Scripture-Adams DD, Brooks DG, Korin YD, Zack JA.

J Virol. 2002 Dec;76(24):13077-82.(PDF)

Activation of CD8 T cells induces expression of CD4, which functions as a chemotactic receptor.

Kitchen SG, LaForge S, Patel VP, Kitchen CM, Miceli MC, Zack JA.

Blood. 2002 Jan 1;99(1):207-12.(PDF)

Impaired response to HAART in HIV-infected individuals with high autonomic nervous system activity.

Cole SW, Naliboff BD, Kemeny ME, Griswold MP, Fahey JL, Zack JA.

Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12695-700.(PDF)

Generation of HIV latency during thymopoiesis.

Brooks DG, Kitchen SG, Kitchen CM, Scripture-Adams DD, Zack JA.

Nat Med. 2001 Apr;7(4):459-64.(PDF)

Progression to the G1b phase of the cell cycle is required for completion of human immunodeficiency virus type 1 reverse transcription in T cells.

Korin YD, Zack JA.

J Virol. 1998 Apr;72(4):3161-8.(PDF)

Transient renewal of thymopoiesis in HIV-infected human thymic implants following antiviral therapy.

Withers-Ward ES, Amado RG, Koka PS, Jamieson BD, Kaplan AH, Chen IS, Zack JA.

Nat Med. 1997 Oct;3(10):1102-9.(

The SCID-hu mouse as a model for HIV-1 infection.

Aldrovandi GM, Feuer G, Gao L, Jamieson B, Kristeva M, Chen IS, Zack JA.

Nature. 1993 Jun 24;363(6431):732-6.

HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure.

Zack JA, Arrigo SJ, Weitsman SR, Go AS, Haislip A, Chen IS.

Cell. 1990 Apr 20;61(2):213-22. (PDF)

HIV-1 production from infected peripheral blood T cells after HTLV-I induced mitogenic stimulation.

Zack JA, Cann AJ, Lugo JP, Chen IS.

Science. 1988 May 20;240(4855):1026-9.