Xing Laboratory of RNA Genomics and Bioinformatics

Welcome to the Xing Laboratory of RNA Genomics and Bioinformatics!

Current Research Topics:
The long-term goal of our research is to elucidate how genomic and environmental variation of RNA regulatory networks impacts phenotypic traits and diseases. We are a hybrid computational and experimental lab. We combine genomic, bioinformatic, molecular, and network approaches to study mRNA processing and post-transcriptional gene regulation in mammalian cells. We develop novel computational and statistical methods for analysis of massive genome and transcriptome data. We integrate computational studies with high-throughput and experimental research to systematically investigate the variation and dynamics of RNA regulatory networks between species, within human populations, and in response to developmental and disease signals.

Recent News

  • April 2016: Shihao's SURVIV paper has been accepted for publication by Nature Communications. SURVIV is a statistical method for survival analysis of mRNA isoform variation in cancer transcriptomes.

  • April 2016: Jinkai's work on m6A-LAIC-seq (m6A level and isoform characterization sequencing) has been accepted for publication by Nature Methods.

  • January 2016: Lan's work on primate-specific, protein-coding Alu exons has been published and highlighted by Genome Biology ("Proteome diversification by genomic parasites"; research highlight by Eli Eisenberg).