Welcome to the Xing Laboratory of RNA Genomics and Bioinformatics!
Current Research Topics:
The long-term goal of our research is to elucidate how genomic and environmental variation of RNA regulatory networks impacts phenotypic traits and diseases.
We are a hybrid computational and experimental lab. We combine genomic, bioinformatic, molecular, and network approaches to study mRNA processing and
post-transcriptional gene regulation in mammalian cells. We develop novel computational and statistical methods for analysis of massive genome and transcriptome data.
We integrate computational studies with high-throughput and experimental research to systematically investigate
the variation and dynamics of RNA regulatory networks between species, within human populations, and in response to developmental and disease signals.
Nov 2014: Shihao and Juw Won's rMATS paper has been accepted for publication by PNAS. rMATS is a computational tool to detect differential alternative splicing events from replicate RNA-Seq data. [rMATS software]
Oct 2014: Shihao received a 2-year Human Biology Fellowship from the Huntington’s Disease Society of America (HDSA) on “Transcriptome Isoform Networks in Huntington’s Disease”. Congratulations! [HDSA press release]
Oct 2014: We received a Developmental Research Program Award from the UCLA SPORE in Prostate Cancer.
Sep 2014: Jinkai's work in collaboration with Drs. Cosmas Giallourakis (MGH) and Howard Chang (Stanford) on m6A RNA methylation of mammalian embryonic stem cells is in press at Cell Stem Cell.
Sep 2014: We received a 2-year R01 grant from the NIH Roadmap Initiative to study epigenomic control of RNA processing.
Aug 2014: Our work in collaboration with Dr. Yang Shi (Harvard) on a chromatin regulator of intron retention has been accepted for publication by Molecular Cell.