Xing Laboratory of RNA Genomics and Bioinformatics

Welcome to the Xing Laboratory of RNA Genomics and Bioinformatics!

Current Research Topics:
The long-term goal of our research is to elucidate how genomic and environmental variation of RNA regulatory networks impacts phenotypic traits and diseases. We are a hybrid computational and experimental lab. We combine genomic, bioinformatic, molecular, and network approaches to study mRNA processing and post-transcriptional gene regulation in mammalian cells. We develop novel computational and statistical methods for analysis of massive genome and transcriptome data. We integrate computational studies with high-throughput and experimental research to systematically investigate the variation and dynamics of RNA regulatory networks between species, within human populations, and in response to developmental and disease signals.

Recent News

  • Oct 2014: Shihao received a 2-year Human Biology Fellowship from the Huntington’s Disease Society of America (HDSA) on “Transcriptome Isoform Networks in Huntington’s Disease”. Congratulations! [HDSA press release]

  • Oct 2014: We received a Developmental Research Program Award from the UCLA SPORE in Prostate Cancer.

  • Sep 2014: Jinkai's work in collaboration with Drs. Cosmas Giallourakis (MGH) and Howard Chang (Stanford) on m6A RNA methylation of mammalian embryonic stem cells is in press at Cell Stem Cell.

  • Sep 2014: We received a 2-year R01 grant from the NIH Roadmap Initiative to study epigenomic control of RNA processing.

  • Aug 2014: Our work in collaboration with Dr. Yang Shi (Harvard) on a chromatin regulator of intron retention has been accepted for publication by Molecular Cell.

  • Oct 2013: Our work with Beverly Davidson (University of Iowa) on mapping microRNA binding sites in the human brain will appear in the journal Neuron.

  • Sep 2013: We received a 5-year NIH R01 grant (R01NS076631) from the National Institute of Neurological Disorders and Stroke (NINDS) to study the transcriptome landscape of Huntington's disease.

  • Jun 2013: Dr. Yi Xing is appointed as a regular member of the NIH GCAT (Genomics, Computational Biology and Technology) study section (2013-2019).

  • Feb 2013: Dr. Yi Xing received a 2013 Alfred P. Sloan Research Fellowship. [Sloan Foundation news] [UCLA news]