THE ENZYMES
Third Edition
Elsevier/ Academic Press
Amsterdam Boston Heidelberg London New York Oxford Paris San Diego San Francisco
Sydney Tokyo
New Volume to be Published in 2006
The Enzymes Vol. 24
Protein methyltransferase
Steven G. Clarke and Fuyuhiko Tamanoi
Protein methylation has recently emerged as one of the most exciting areas of study on posttranslational modification. A large family of protein methyltransferases has been identified and their structural properties have been characterized. These studies have provided novel insights into how methylation regulates a variety of biological functions including DNA and RNA metabolism, protein synthesis and signal transduction. Methylation also plays important roles in aging. This volume is intended to capture these recent developments concerning protein methyltransferases.
Part I: Overview of Protein Methyltransferases
Chapter 1: Protein methyltransferases: Their distribution among the five structural classes of AdoMet-dependent methyltransferase: Heidi L. Schubert, Robert M. Blumenthal and Xiaodong Cheng
Part II: Modification of Lysine and Arginine Residues
in Signal Transduction, Transcription, Translation, and Other Functions
Chapter 2: The family of protein arginine methyltransferases: Mark
T. Bedford, University of Texas MD Anderson Cancer Center, Smithville, Texas
Chapter 3: Diverse roles of protein arginine methyltransferases: Anne E. McBride,
Bowdoin College, Brunswick, Maine
Chapter 4: Structure of protein arginine methyltransferases: Xing Zhang and
Xiaodong Cheng, Emory University, Atlanta, Georgia
Chapter 5: Methylation and demethylation of histone Arg and Lys residues in
chromatin structure and function: Yanming Wang, Rockefeller University
Chapter 6: Structure of SET domain protein lysine methyltransferases: Bing
Xiao, Steven J. Gamblin and Jonathan R. Wilson, Division of Molecular Structure,
NIMR, London, UK
Chapter 7: Non-histone protein lysine methyltransferases - structure and catalytic
roles: Lynnette M.A. Dirk, Raymond C. Trievel and Robert L. Houtz, University
of Kentucky, Louisville, KY
Chapter 8: Demethylation pathways for histone methyllysine residues: Federico
Forneris, Claudia Binda, Maria Antonietta Vanoni, Andrea Mattevi and Elena
Battaglioli, University of Pavia
Part III: Biological Regulation by Protein Methyl Ester Formation
Chapter 9: Structure and function of isoprenylcyseteine carboxylmethyltransferase
(Icmt), a key enzyme in CaaX processing: Jessica L. Anderson and Christine
A. Hrycyna, Purdue University
Chapter 10: Genetic approaches for understanding the physiologic importance
of the carboxyl methylation of the isoprenylated proteins: Stephen G. Young,
Steven Clarke, Martin O. Bergo, Mark Philips and Loren G. Fong, UCLA
Chapter 11: Reversible methylation of protein phosphatase 2A: Sari Longin
and Jozef Goris, Afdeling Biochemie, Katholieke Universiteit Leuven
Chapter 12: Reversible methylation of glutamate residues in the receptor proteins
of bacterial sensory sytems: Frances M. Antomattei and Robert M. Weiss, Universtiy
of Massachusetts
Part IV: Recognition of Damaged Proteins in Aging by Protein Methyltransferases
Chapter 13: Protein L-isoapartyl/D-aspartyl O-methyltransferases: Clare M. O'Connor, Boston College, Chestnut Hill, MA
Part V: Modification of Proteins by Methylation at Glutamine and Asparagine Residues
Chapter 14: Modification of glutamine residues in proteins involved
in translation: Heidi Schubert, University of Utah
Chapter 15: Modification of phycobiliproteins at asparagine residues: Alan
V. Klotz, Eli Lilly
Part VI: Inhibition of Methyltransferases by Metabolites
Chapter 16: Inhibition of mammalian protein methyltransferases by 5'-methyladenosine(MTA): A mechanism of action of dietary SAMe?: Steven G. Clarke, UCLA
Recent Volumes
Vol. 23 (2003) Energy Coupling and Molecular Motors
This volume examines a number of different molecular motors that utilize ATP. The molecular machines to be discussed include ATP synthase, myosin, kinesin, DNA helicases, DNA topoisomerases, chaperones and bacterial rotory motors. The discussion of these various molecular motors is rarely undertaken in one volume and will serve as a great resource for scientists studying structure and function of multiprotein complexes as well as those working on energy coupling mechanisms. The areas of research presented in this volume do not normally overlap, and yet they share common mechanisms.
Vol. 22 (2001) Co- and Posttranslational Proteolysis of Proteins
This
volume examines a number of different proteases, a type of enzyme, that are
required in order for the change to a biologically active mature protein to
occur. The discussion of these various proteases is rarely undertaken in one
volume and will serve as a great resource for scientists studying the group
of proteases on signal peptide processing as well as those working on propeptide
processing. These areas of research do not normally overlap, and yet they
are each of common importance to the same cell processes.
Vol. 21 (2000) Protein Lipidation
This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein lipidation, a process critical for a number of physiological functions, including cell proliferation and morphology. Inhibitors of protein lipidation have recently been shown to be useful as anticancer drugs. Enzymatic mechanisms, mutational analysis, and structural studies are presented.
Fuyu Tamanoi University of California, Los Angeles
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Archives
Vol. 20 (1992) Mechanisms of Catalysis, edited by David S. Sigman
Vol. 19 (1990) Mechanisms of Catalysis, edited by David S. Sigman and Paul D. Boyer
Vol. 18 (1987) Control by Phosphorylation Part B: Specific enzymes (ll); biological processes, edited by Paul D. Boyer and Edwin G. Krebs
Vol. 17 (1986) Control by Phosphorylation Part A: General features; specific enzymes (l), edited by Paul D. Boyer and Edwin G. Krebs
Vol. 16 (1983) Lipid Enzymology: fatty acids; glycerides; phospholipids; sphingolipids; glycolipids, cholesterol; special topics, edited by Paul D. Boyer
Vol. 15 (1982) Nucleic Acids Part B, edited by Paul D. Boyer
Vol. 14 (1981) Nucleic Acids Part A, edited by Paul D. Boyer
Vol. 13 (1976) Oxidation-reduction Part C: Dehydrogenases (ll); oxidases (ll); hydrogen peroxide cleavage, edited by Paul D. Boyer
Vol. 12 (1975) Oxidation-reduction Part B: Electron transfer (ll); oxygenases; oxidases (l), edited by Paul D. Boyer
Vol. 11 (1975) Oxidation-Reduction Part A: Dehydrogenases (l); Electrion transfer (l), edited by Paul D. Boyer
Vol. 10 (1974) Protein Synthesis; DNA synthesis and repair; RNA synthesis; energy-linked ATPases; synthetases, edited by Paul D. Boyer
Vol. 9 (1973) Group transfer (Part B). Phosphoryl transfer; one-carbon group transfer; glycosyl transfer:amino group transfer, edited by Paul D. Boyer
Vol. 8 (1973) Nucleotidyl Transfer; nucleosidyl transfer; acyl transfer; phosphoryl transfer, edited by Paul D. Boyer
Vol. 7 (1972) Elimination and addition aldol cleavage and condensation other C-C cleavage; Phosphorolysis; hydrolysis (fats, glycosides), edited by Paul D. Boyer
Vol. 6 (1972) Carboxylation and decarboxylation (nonoxidative); isomerization, edited by Paul D. Boyer
Vol. 5 (1971) Hydrolisis; sulfate esters; carboxyl esters; glycosides, edited by Paul D. Boyer
Vol. 4 (1971) Hydrolisis; other C-N bonds; phosphate esters, edited by Paul D. Boyer
Vol. 3 (1971) Hydrolisis; peptide bonds, edited by Paul D. Boyer
Vol. 2 (1970) Kinetics and mechanism, edited by Paul D. Boyer
Vol. 1 (1970) Structure and control, edited by Paul D. Boyer