Recent Publications

  1. Lu J, Choi E, Zink JI, Tamanoi F.  Light-Activated Nanoimpeller-Controlled Drug Release in Cancer Cells. Offsite Link  Small.  2008 March 31.
  2. Lu J, Liong M, Zink JI, Tamanoi F.  Mesoporous Silica Nanoparticles for Cancer Therapy: Energy-Dependent Cellular Uptake and Delivery of Paclitaxel to Cancer Cells. Offsite Link  NanoBiotechnology.  2008 Feb 20.
  3. Watanabe M, Fiji HD, Guo L, Chan L, Kinderman SS, Slamon DJ, Kwon O, Tamanoi F. Inhibitors of protein geranylgeranyltransferase-I and rab geranylgeranyltransferase identified from a library of allenoate derived compounds. Offsite Link  J Biol Chem.  2008 Jan 28.
  4. Aspuria PJ, Tamanoi F. The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast. Offsite Link  Mol Genet Genomics.  2008 Jan 25.
  5. Aspuria PJ, Sato T, Tamanoi F.  The TSC/Rheb/TOR Signaling Pathway in Fission Yeast and Mammalian Cells: Temperature Sensitive and Constitutive Active Mutants of TOR. Offsite Link  Cell Cycle.  2007 May 21;6(14): 1692-5.
  6. Lu J, Liong M, Zink JI, Tamanoi F.  Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs. Offsite Link  Small.  2007 Jun 13.
  7. Urano J, Sato T, Matsuo T, Otsubo Y, Yamamoto M, Tamanoi F.  Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells. Offsite Link  Proc Natl Acad Sci U S A.  2007 Feb; 104 (9):3514-3519.
  8. Patel PH, Tamanoi F.  Increased Rheb-TOR signaling enhances sensitivity of the whole organism to oxidative stress. Offsite Link  J Cell Sci.  2006 Oct 15;119(Pt 20):4285-92.
  9. Khazak V, Kato-Stankiewicz J, Tamanoi F, and Golemis E.A.  Yeast screens for inhibitors of Ras-Raf interaction and characterization of MCP inhibitors of Ras-Raf interaction. Offsite Link  Methods in Enzymology.  2005;407:612-29.
  10. Urano J, Comiso MJ, Guo L, Aspuria PJ, Deniskin R, Tabancay AP Jr, Kato-Stankiewicz J, Tamanoi F.  Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast. Offsite Link  Molecular Microbiology.  2005 Nov; 58(4):1074-86.
  11. Gau GL, Kato-Stankiewicz J, Jiang C, Miyamoto S, Guo L, Tamanoi F.  Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways. Offsite Link  Mol Cancer Ther.  2005 Jun;4(6):918-26.
  12. Kho Y, Kim SC, Jiang C, Barma D, Kwon SW, Cheng J, Jaunbergs J, Weinbaum C, Tamanoi F, Falck J, Zhao Y.  A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. Offsite Link  Proc Natl Acad Sci U S A.  2004 Aug 24;101(34):12479-84. Epub 2004 Aug 12.
  13. Aspuria PJ, Tamanoi F.  The Rheb family of GTP-binding proteins. Offsite Link  Cell Signal.  2004 Oct;16(10):1105-12.
  14. Uhlmann EJ, Li W, Scheidenhelm DK, Gau CL, Tamanoi F, Gutmann DH.  Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation. Offsite Link  Glia.  2004 Aug;47(2):180-8.
  15. Clarke S, Tamanoi F.  Fighting cancer by disrupting C-terminal methylation of signaling proteins. Offsite Link  J Clin Invest.  2004 Feb;113(4):513-5.
  16. Patel PH, Thapar N, Guo L, Martinez M, Maris J, Gau CL, Lengyel JA, Tamanoi F.  Drosophila Rheb GTPase is required for cell cycle progression and cell growth.  J Cell Sci.  2003 Sep 1;116(Pt 17):3601-10.
  17. Tabancay AP Jr, Gau CL, Machado IM, Uhlmann EJ, Gutmann DH, Guo L, Tamanoi F.  Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K. Offsite Link  J Biol Chem.  2003 Oct 10;278(41):39921-30. Epub 2003 Jul 17.
  18. Hamasaki A, Naka H, Tamanoi F, Umezawa K, Otsuka M.  A novel metal-chelating inhibitor of protein farnesyltransferase. Offsite Link  Bioorg Med Chem Lett.  2003 May 5;13(9):1523-6.
  19. Kato-Stankiewicz J, Hakimi I, Zhi G, Zhang J, Serebriiskii I, Guo L, Edamatsu H, Koide H, Menon S, Eckl R, Sakamuri S, Lu Y, Chen QZ, Agarwal S, Baumbach WR, Golemis EA, Tamanoi F, Khazak V.  Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells. Offsite Link  Proc Natl Acad Sci U S A.  2002 Oct 29;99(22):14398-403. Epub 2002 Oct 21.
  20. Finlin BS, Gau CL, Murphy GA, Shao H, Kimel T, Seitz RS, Chiu YF, Botstein D, Brown PO, Der CJ, Tamanoi F, Andres DA, Perou CM.  RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. Offsite Link  J Biol Chem.  2001 Nov 9;276(45):42259-67. Epub 2001 Aug 31.
  21. Pervin S, Singh R, Gau CL, Edamatsu H, Tamanoi F, Chaudhuri G.  Potentiation of nitric oxide-induced apoptosis of MDA-MB-468 cells by farnesyltransferase inhibitor: implications in breast cancer.  Cancer Res. 2001 Jun 15;61(12):4701-6.
  22. Tamanoi F, Kato-Stankiewicz J, Jiang C, Machado I, Thapar N.  Farnesylated proteins and cell cycle progression. Offsite Link  J Cell Biochem Suppl.  2001;Suppl 37:64-70. Review.
  23. Tamanoi F, Gau CL, Jiang C, Edamatsu H, Kato-Stankiewicz J. Protein farnesylation in mammalian cells: effects of farnesyltransferase inhibitors on cancer cells.  Cell Mol Life Sci.  2001 Oct;58(11):1636-49. Review.
  24. Yang W, Tabancay AP Jr, Urano J, Tamanoi F. Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant.  Mol Microbiol.  2001 Sep;41(6):1339-47.
  25. Urano J, Ellis C, Clark GJ, Tamanoi F. Characterization of Rheb functions using yeast and mammalian systems.  Methods Enzymol.  2001;333:217-31. No abstract available.
  26. Guo W, Tamanoi F, Novick P.  Spatial regulation of the exocyst complex by Rho1 GTPase.  Nat Cell Biol. 2001 Apr;3(4):353-60.
  27. Urano J, Tabancay AP, Yang W, Tamanoi F.  The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake. Offsite Link  J Biol Chem. 2000 Apr 14;275(15):11198-206.
  28. Edamatsu H, Gau CL, Nemoto T, Guo L, Tamanoi F.  Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines. Offsite Link  Oncogene.  2000 Jun 22;19(27):3059-68.
  29. Yang W, Urano J, Tamanoi F.  Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe. Offsite Link  J Biol Chem.  2000 Jan 7;275(1):429-38.