TSC/Rheb/mTOR Signaling Pathway - related publications 2000-Present
Hardt M, Chantaravisoot N, Tamanoi F. Activating mutations of TOR (target of rapamycin). Genes Cells. 2011 Feb;16(2):141-51.
Chandaravisoot, N. and Tamanoi F. TOR Signaling and Human Cancer. The Enzymes 2010; 28: 301-314.
Parmar N. and Tamanoi F. Rheb G-Proteins and the Activation of mTORC1. The Enzymes 2010; 27: 39-53.
Sato T, Nakashima A, Guo L, Coffman K, Tamanoi F. Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer. Oncogene. 2010 Mar 1.
Nakashima A, Sato T, Tamanoi F. Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin. J Cell Sci. 2010 Mar 1;123(Pt 5):777-86. Epub 2010 Feb 9.
Sato T, Nakashima A, Tamanoi F. Tanpakushitsu Kakusan Koso. Rheb-mTOR signaling pathway involved in tumor formation.2010 Jan;55(1):11-7. Review. Japanese.
Sato T, Nakashima A, Guo L, Tamanoi F. Specific activation of mTORC1 by RHEB G-protein in vitro involves enhanced recruitment of its substrate protein. J Bio Chem. 2009 Mar 20.
Sato T, Umetsu A, Tamanoi F. Characterization of the Rheb-mTOR Signaling Pathway in Mammalian Cells: Constitutive Active Mutants of Rheb and mTOR. Methods in Enzymol. 2008
Aspuria PJ, Tamanoi F. The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast. Mol Genet Genomics. 2008 Jan 25.
Aspuria PJ, Sato T, Tamanoi F. The TSC/Rheb/TOR Signaling Pathway in Fission Yeast and Mammalian Cells: Temperature Sensitive and Constitutive Active Mutants of TOR. Cell Cycle. 2007 May 21;6(14): 1692-5.
Urano J, Sato T, Matsuo T, Otsubo Y, Yamamoto M, Tamanoi F. Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells. Proc Natl Acad Sci U S A. 2007 Feb; 104 (9):3514-3519.
Patel PH, Tamanoi F. Increased Rheb-TOR signaling enhances sensitivity of the whole organism to oxidative stress. J Cell Sci. 2006 Oct 15;119(Pt 20):4285-92.
Urano J, Comiso MJ, Guo L, Aspuria PJ, Deniskin R, Tabancay AP Jr, Kato-Stankiewicz J, Tamanoi F. Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast. Molecular Microbiology. 2005 Nov; 58(4):1074-86.
Kho Y, Kim SC, Jiang C, Barma D, Kwon SW, Cheng J, Jaunbergs J, Weinbaum C, Tamanoi F, Falck J, Zhao Y. A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12479-84. Epub 2004 Aug 12.
Aspuria PJ, Tamanoi F. The Rheb family of GTP-binding proteins. Cell Signal. 2004 Oct;16(10):1105-12.
Uhlmann EJ, Li W, Scheidenhelm DK, Gau CL, Tamanoi F, Gutmann DH. Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation. Glia. 2004 Aug;47(2):180-8.
Clarke S, Tamanoi F. Fighting cancer by disrupting C-terminal methylation of signaling proteins. J Clin Invest. 2004 Feb;113(4):513-5.
Patel PH, Thapar N, Guo L, Martinez M, Maris J, Gau CL, Lengyel JA, Tamanoi F. Drosophila Rheb GTPase is required for cell cycle progression and cell growth. J Cell Sci. 2003 Sep 1;116(Pt 17):3601-10.
Tabancay AP Jr, Gau CL, Machado IM, Uhlmann EJ, Gutmann DH, Guo L, Tamanoi F. Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K. J Biol Chem. 2003 Oct 10;278(41):39921-30. Epub 2003 Jul 17.
Yang W, Tabancay AP Jr, Urano J, Tamanoi F. Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant. Mol Microbiol. 2001 Sep;41(6):1339-47.
Urano J, Ellis C, Clark GJ, Tamanoi F. Characterization of Rheb functions using yeast and mammalian systems. Methods Enzymol. 2001;333:217-31. No abstract available.
Guo W, Tamanoi F, Novick P. Spatial regulation of the exocyst complex by Rho1 GTPase. Nat Cell Biol. 2001 Apr;3(4):353-60.
Urano J, Tabancay AP, Yang W, Tamanoi F. The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake. J Biol Chem. 2000 Apr 14;275(15):11198-206.
Edamatsu H, Gau CL, Nemoto T, Guo L, Tamanoi F. Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines. Oncogene. 2000 Jun 22;19(27):3059-68.
Yang W, Urano J, Tamanoi F. Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe. J Biol Chem. 2000 Jan 7;275(1):429-38.