Molecular Microbiology

 Molecu lar and cellular approaches to the immunobiology and immuno pathogenesis of syphilis and Lyme borreliosis: (a) development of an early disease rabbit model for Lyme borreliosis, (b) vaccine development utilizing recombinant molecules, (c) operative humoral and cell-mediated immune mechanisms in the acquired and neonatal infection, (d) antigenic interrelationships and structure-function analysis of surface and subsurface molecules, and (e) mechanisms of cellular attachment.

BLANCO, D.R., REIMANN, K., SKARE, J.T., CHAMPION, C.I., FOLEY, D.M., EXNER, M.M., HANCOCK, R.E.W., MILLER, J.N., and LOVETT, M.A. "Isolation of the Outer Membranes from Treponema pallidum and Treponema vincentii." J. Bacteriol., 176:6088-6099, 1994.

 BLANCO, D.A., CHAMPION, C.I., EXNER, M.M., ERDJUMENT-BROMAGE, H., HANCOCK, R.E.W., TEMPST, P., MILLER, J.N., and LOVETT, M.A. ³Porin Activity and Sequence Analysis of a 31-Kilodalton Treponema pallidum subsp. pallidum Rare Outer Membrane Protein (Tromp1).² J. Bacteriol., 177:3556-3562, 1995.

 FOLEY, D.M., GAYEK, R.J., SKARE, J.T., WAGAR, E.A., CHAMPION, C.I., BLANCO,D.R., LOVETT, M.A., and MILLER, J.N. ³Rabbit Model of Lyme Borreliosis: Erythema Migrans, Infection-Derived Immunity, and Identification of B. burgdorferi Proteins Associated with Virulence and Protective Immunity.² J. Clin. Invest., 96:965-975, 1995.

 SKARE, J.T., SHANG, E.S., FOLEY, D.M., BLANCO, D.R., CHAMPION, C.I., MIRZABEKOV. T., SOKOLOV, Y., KAGAN, B.L., MILLER, J.N., and LOVETT, M.A. ³Virulent Strain-Associated Outer Membrane Proteins of Borrelia burgdorferi.² J. Clin. Invest. 96:2380-2392, 1995.

 BLANCO, D.R., MILLER, J.N., and LOVETT, M.A. "Surface Antigens of the Syphilis Spirochete and Their Potential as Virulence Determinants." Emerg. Infect. Dis. Emerg. Infect. Dis., 3:11-20, 1997.