Deng, JC., Cheng, G. Newstead, MW., Zeng, X., Kobayashi, K., Flavell, R., Standiford, TJ. Sepsis-Induced Suppression of Lung Innate Immunity is Mediated by IRAK-M. The Journal of clinical investigation In press. 2006

Saha, SK and Cheng, G. TRAF3: A New Regulator of Type I Interferons. Cell Cycle. 2006 Apr 17;5(8) [Epub ahead of print]

Miller, LS., O'Connell, RM., Gutierrez, MA., Pietras, EM., Shahangian, A., Gross, CE., Thirumala, A., Cheung, AL., Cheng , G. , Modlin, RL. MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus Immunity, 24:79-91, 2006.

Oganesyan, G., Saha, SK, Guo, B., He, J., Shahangian, A., Zarnegar B., Perry, AK., Cheng, G. Critical role of TRAF3 in the Toll-like receptor-dependent and independent antiviral response. Nature, 439:208-211, 2006.

Chow, EK., O'Connell, RM, Schilling, S., , Wang, XF., Fu, XY., and Cheng , G. TLR Agonists Regulate PDGF-B Production and Cell Proliferation through TGF-beta/Type I IFN Crosstalk EMBO J. 24:4071-4081, 2005.

Perry, AK., Chen, G., Zheng, DH., Tang, H., Cheng, G. The host type I interferon response to viral and bacterial infections. Cell Res. 15:407-422, 2005.

Shen, DX., Ke, B., Zhai, Y., Gao, F., Busuttil, RW., Cheng, G., Kupiec-Weglinski, JW. Toll-Like Receptor and Heme Oxygenase-1 Signaling in Hepatic Ischemia/Reperfusion Injury. Am J Transplant. 5:1793-800, 2005.

O'Connell, RM, Saha, SK and Cheng, G. Combating bacterial pathogens through host defense gene programs. Current Immunology Reviews, 1:43-54, 2005.

Chin,AI., Dempsey, PW. And Cheng, G. Rip2: a key molecule that regulates both innate and acquired immunity. Current Medicinal Chemistry, 4:35-42, 2005.

O'Connell, RM, Vaidya, VA, Perry, AK, Saha, SK, Dempsey, PW., and Cheng, G. Immune activation of type I IFNs by Listeria monocytogenes occurs independent of TLR4, TLR2 and receptor interacting protein 2 but involves tank-binding kinase 1. J. Immunol., 174:1602-1607, 2005.

Liu, B., Wong, KA., Getman, C., Gao, J., Teitell, M., Cheng, G., Wu., H., and Shuai K. A Negative Regulation of NF-kB Signaling by PIAS1. Mol. Cell. Biol. 25:1113-23, 2005.
Jazirehi, AR., Huerta-Yepez, S., Cheng, G. and Bonavida, B. Rituximab (chimeric anti-CD20 mAb) inhibits the constitute NIK/IKK/I B/NF- B signaling pathway in non-Hodgkin's lymphoma (NHL) B-cell lines: role in sensitization to chemotherapeutic drug-induced apoptosis. Cancer Research, 65:264-276, 2005

Ni, CZ, Oganesyan, G., Welsh, K., Zhu, X., Reed, JC., Satterthwait, AC., Cheng, G., and Ely, KR. Key Molecular Contacts Promote Recognition of BAFF Receptor by TNF Receptor-Associated Factor 3: Implications for Intracellular Signaling Regulation. J. Immunol., 173: 7394-7400, 2004.

Zhai, Y., Shen, X., O'Connell, R., Gao, F., Lassman, C., Busuttil, RW., Cheng, G., Kupiec-Weglinski, JW. TLR4 Activation Mediates Liver Ischemia/Reperfusion Inflammatory Response via IFN Regulatory Factor 3-Dependent MyD88-Independent Pathway. J. Immunol., 173: 7115-7119, 2004.

Modlin, RL. And Cheng, G. From plankton to pathogen recognition. Nature Medcine, 10:1173-1174, 2004.

Joseph, S.B., Bradley, M.N., Castrillo, A., Bruhn, K.W., Mak, P.A., Liming, P., Hogenesch, J., O'Connell, RM., Cheng, G., Saez, E., Miller, J.F. and Tontonoz, P. LXR-dependent gene expression is important for macrophage survival and the innate immune response to bacterial pathogens. Cell, 119: 299-309, 2004.

O'Connell, RM, Saha, SK., Vaidya SA, Bruhn, KW., Gustavo A. Miranda, GA., Brian Zarnegar, B., Perry, AK., Nguyen, B., Lane, TF., Taniguchi, T., Miller, JF., and Cheng, G. Type I Interferon production enhances susceptibility to Listeria monocytogenes infection. J Exp Med., 200:437-445, 2004.

Perry, AK., Chow, EK., Goodnough, JB.,, Yeh, WC., and Cheng, G. Differential Requirement for TANK-Binding Kinase-1 in Type I Interferon Responses to Toll-like Receptor Activation and Viral Infection. J Exp Med., 199:1651-1658, 2004.

Huerta-Yepez, S., Vega, M., Jazirehi, A., Garban., H., Hongo, F., Cheng, G., and Bonavida, B. Nitric oxide sensitize prostate carcinoma cell lines to TRAIL-mediated apoptosis via inactivation of NF- B and inhibition of Bcl-xL expression. Oncogene, 23:4993-5003, 2004.

Zarnegar B., He, J., Oganesyan, G., Hoffmann, A., Baltimore, D. and Cheng G. Unique CD40-mediated biological program in B-cell activation requires both type 1 and type 2 NF- B activation pathways. Proc. Natl. Acad. Sci. USA, 101:8108-8113, 2004.

Doyle, S. E., O'Connell, R. M., Miranda, G. A., Vaidya, S. A., Chow, E. K., Liu, P. T., Suzuki, S., Suzuki, N., Modlin, R. L., Yeh, W. -C., Lane, F. T. and Cheng, G. Toll-like Receptors Induce a Phagocytic Gene Program through p38. J Exp Med., 199:81-90. 2004.

Dadgostar, H., Doyle, S. E., Shahangian, A., Garcia, D. E., and Cheng, G. T3JAM, a novel Tumor Necrosis Factor Receptor-Associated Factor 3-interacting protein that allows Tumor Necrosis Factor Receptor-Associated Factor 3 to activate JNK. FEBS L, 553:403-40, 2003.

Dempsey PW, Vaidya SA, and Cheng G. The Art of War: Innate and Adaptive Immune Responses. Cell Mol Life Sci 60:2604-21, 2003.

Castrillo, A., Joseph SB., Vaidya, A., Haberland, M., Fogelman AM., Cheng, G., and Tontonoz, P. Crosstalk Between LXR and Toll-like Receptor Signaling Mediated Bacterial and Viral Antagonism of Cholesterol Metabolism. Molecular Cell 12:805-816, 2003.

Vaidya, S. A. and Cheng, G. Toll-like Receptors and Innate Antiviral Responses. Curr Opin Immunol 15:402-407, 2003.

Brown, HJ., Song, MJ, Deng, H., Wu, TT., Cheng, G., Sun, R. NF-kappaB Inhibits Gammaherpesvirus Lytic Replication. J Virol. 77, 8532-8540, 2003.

Dempsey, P.W., Doyle, S.E., He, J., and Cheng, G. The Signaling Adaptors and Pathways Activated by TNF Superfamily, TRAFs and Death Domains. Cytokines and Growth Factors Review. 14:193-209, 2003.

Doyle, S. E., O'Connell, R., Vaidya, S. A., Chow, E. K., Yee, K., Cheng, G. TLR3 mediates a more potent antiviral response than TLR4. J. Immunol., 170:3565-71, 2003.

Ronni, T. Agarwal, V., Haykinson, M., Haberland, M.E., Cheng, G., Smale, S. T. Common Interaction Surfaces of Toll-Like Receptor 4 Cytoplasmic Domain Stimulate Multiple Nuclear Targets. Mol. Cell. Biol. 23:2543-2555, 2003.

Doyle, S. E., Vaidya, S. A., O'Connell, R., Dadgostar, H., Dempsey, P. W., Wu, T. T., Rao, G., Sun, R., Haberland, M. E., Modlin, R. L., Cheng, G. IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program. Immunity 17:251-263, 2002.

Li, C., Ni, C. Z. , Havert, M., Cabezas, E., He, J., Kaiser, D., Reed, J. C., Satterthwait, A. C., Cheng,, G. and Ely, K. R. Downstream Regulator TANK Binds to the CD40 Recognition Site on TRAF3. Structure 10:403-411, 2002.

Cheng, G. and Schoenberger, S. P. CD40 Signaling and Autoimmunity. Curr Dir Autoimmun 5:51-61, 2002.

Chin, A. I., Dempsey, P. W., Bruhn, K., Miller, J. F., Xu, Y., and Cheng, G. Involvement of Receptor Interacting Protein 2 in Innate and Adaptive Immune Responses. Nature 416:190-194, 2002.

Dadgostar, H., Zarnegar, B., Hoffmann, A., Qin, X. F., Truong, U., Rao, G., Baltimore, D. and Cheng, G. Cooperation of Multiple Signaling Pathways in CD40-Regulated Gene Expression in B Lymphocytes. Proc. Natl. Acad. Sci. USA, 99: 1497-1502, 2002.

Wang, Y, Kelly, C. G., Karttunen, J. T., Whittall, T., Lehner, P. J., Duncan, L., MacAry, P., Younson, J. S., Singh, M., Oehlmann, W., Cheng, G., Bergmeier, L. and Lehner. T. CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines. Immunity 15:971-83, 2001.

Kwan, R., Burnside, J., Kurosaki, T. and Cheng, G. MEKK1 Is Essential for DT40 Cell Apoptosis in Response to Microtubule Disruption. Mol. Cell. Biol. 21:7183-7190, 2001.
Bleharski, J. R., Niazi K. R., Sieling, P. A., Cheng, G., and Modlin, R. L. Signaling lymphocytic activation molecule (SLAM) is expressed on CD40L-activated dendritic cells and directly augments production of inflammatory cytokines. J. Immunol., 167:3174-81, 2001.

Mori, M., Fujii, M., Cheng, G., Ikeda, S., Yamasaki, Y., Yamada, Y., Tomonaga, M., and Yamamoto, N. Human T-cell leukemia virus type I Tax protein induces the expression of anti-apoptotic gene bcl-XL in human T cells through nuclear factor- B and c-AMP pesponsive element binding protein pathways. Virus Genes 22:279-287, 2001.

Chamorro, M., Czar, M. J., Debnath, J, Cheng, G., Lenardo, M. J., Varmus, H. E., and Schwartzberg, P. L. Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk. BMC Immunol. 2:3, 2001.

Fischbein, MP, Ardehali, A., Yun, J. Schoenberger, S., Laks, H., Irie, Y., Dempsey, P., Cheng, G., Fishbein MC, and Bonavida, B. CD40 signaling replaces CD4 lymphocytes and its blocking prevents chronic rejection of heart transplants. J. Immunol. 165: 7316-22, 2000.

Cheng, Q., Lee, H. H., Ying Li, Parks, T., and Cheng, G. Upregulation of Bcl-x and Bfl-1 as a potential mechanism of chemoresistance, which can be overcome by NF- B inhibition. Oncogene 19:4936-4940, 2000.

Jewett, A., Hume, W.R., Lee, H., Cheng, G., and Shi, W. Induction of apoptotic cell death in peripheral blood mononuclear cells and polymorphonuclear cells by oral bacterium F. nucleatum. Infection Immunity 68:1893-1898, 2000.

Dadgostar, H., and Cheng, G. Membrane localization of TRAF 3 enables JNK activation. J. Biol. Chem. 275:2539-2544, 2000.

Lee, H., Dadgostar, H., Shu, J., Cheng, Q., and Cheng, G. The NF- B signal transduction pathway is essential for CD40-mediated up-regulation of the Bcl-x and Bfl-1 genes and B cell survival. Proc. Natl. Acad. Sci. USA 96:9136-9141, 1999.

Chin, A., Shu, J., Shi, C.S., Yao, Z. B., Kehrl, J. H., and Cheng, G. TANK Potentiates Tumor Necrosis Factor Receptor-Associated Factor-Mediated c-Jun N-Terminal Kinase/Stress-Activated Protein Kinase Activation through the Germinal Center Kinase Pathway. Mol. Cell. Biol. 19:6665-6672, 1999.

Lee, H., Demsey, P., Parks, T., Zhu, X., Baltimore, D. and Cheng, G. Specificities of CD40 Signaling: involvement of TRAF2 in CD40-induced NF- B activation and intercellular adhesion molecule-1 up-regulation. Proc. Natl. Acad. Sci. USA 96:1421-1426, 1999.

Dadgostar, H., and Cheng, G. An intact zinc ring finger is required for tumor necrosis factor receptor-associated factor-mediated nuclear factor-kappaB activation but is dispensable for c Jun N-terminal kinase signaling. J. Biol. Chem. 273: 24775-24780, 1998.
Posern, G., Zheng, J., Knudsen, B. S., Muller, K. B., Voss, J., Shishido, T., Cowburn, D., Cheng, G., Wang, B., Kruh, G. D., Burrell, S. K., Jacobson, C. A., Lenz, D. M., Zamborelli, T. J., Adermann, K., Hanafusa, H., and Feller, S. M. Development of highly selective SH3 binding peptides for Crk and CRKL which disrupt Crk-complexes with DOCK180, SOS and C3G. Oncogene 16:1903-1912, 1998.

Brodeur, S. R., Cheng, G., Baltimore, D., and Thorley-Lawson, D. A. Localization of the major NF- B activation site and the sole TRAF3 binding site of LMP-1 defines two distinct signalling motifs. J. Biol. Chem. 272: 19777-19784, 1997.

Rao, G., Rekhtman, N., Cheng, G., Krasikov, T., and Skoultchi, A. I. Deregulation expression of the PU.1 transcription factor blocks murine erythroleukemia cell terminal differentiation. Oncogene 14:123-131, 1997.

Xu, Y., Cheng, G., and Baltimore, D. Targeted disruption of TRAF3 leads to postnatal lethality and defective T dependent immune responses. Immunity 5: 407-415, 1996.
Cheng, G., and Baltimore D. TANK, a novel TRAF2 domain of TNF and CD40L-mediated NF- B activation. Genes Devel. 10:963 973, 1996.

Sirotkin, A. M., Edelmann, W., Cheng, G., Klein Szanto, A., Kucherlapati, R., and Skoultchi, A., Mice develop normally without the Hl° linker histone. Proc. Natl. Acad. Sci. USA 92:6434 6438, 1995.

Alexandropoulos, K., Cheng. G., and Baltimore, D. Proline rich sequences that bind to Src homology 3 domains with individual specificities. Proc. Natl. Acad. Sci. USA 92:3110 3114, 1995.

Baltimore, D., Ren, R., Cheng, G., Alexandropoulos, K., and Cicchetti P. A nuclear tyrosine kinase becomes a cytoplasmic oncogene. Ann N Y Acad Sci 758:339-44, 1995
Cheng, G., Cleary, A. M., Ye, Z. S., Hong, D. I., Lederman, S., and Baltimore, D. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science 267:1494-1498, 1995.

Saksela K., Cheng, G., and Baltimore, D. Proline-rich (PXXP) motifs in HIV Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for downregulation of CD4." EMBO J. 14:484 491, 1995.
Cheng, G., Ye, Z. S., and Baltimore, D. Binding of Bruton's tyrosine kinase (Btk) to Fyn, Lyn or Hck through an SH3 mediated interaction. Proc. Natl. Acad. Sci. USA 91:8152 8155, 1994.

Krimer D. B., Cheng, G., and Skoultchi, A. I. Induction of H3.3 replacement histone mRNAs during the precommitment period of murine erythroleukemia cell differentiation. Nucleic Acids Res. 21(12):2873 2879, 1993.

Schubart, U. K., Xu, J., Fan, W., Cheng, G., Goldstein, H., Alpini, G., Shafritz, D. A., Amat, J. A., Farooq, M., Norton, W. T., Owen, T. A., Lian, J. B., and Stein, G. S. Widespread differentiation stage specific expression of the gene encoding phosphoprotein p19 (metablastin) in mammalian cells. Differentiation 51(1):21 32, 1992.

Cheng, G. Isolation and characterization of two mouse H1 histone genes encoding differentiation inducible polyA+ mRNAs. Ph. D. Thesis, Albert Einstein College of Medicine, 1990.

Cheng,G., Nandi, A., Clerk, S., and Skoultchi, A. I. Different 3'-end processing procedures in two independently regulated mRNAs from a single H1 histone gene. Proc. Natl. Acad. Sci. USA 86:7002 7006, 1989.

Cheng, G., and Skoultchi, A. I. Rapid induction of polyadenylated H1 histone mRNAs in mouse erythroleukemia cells is regulated by c myc. Mol. Cell. Biol. 9:2332 2340, 1989.
Lachman, H. M., Cheng, G., and Skoultchi, A. I. Transfection of mouse erythroleukemia cells with myc sequences changes the rate of induced commitment to differentiate. Proc. Natl. Acad. Sci. USA 83:6380 6484, 1986.
 

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