About the PI

Updated on Jan, 2011

Genhong Cheng, Ph.D.

Professor
Dept. of Microbiology, Immunology & Molecular Genetics
University of California, Los Angeles
BSRB 210A
615 E. Charles Young Dr.
Los Angeles, CA 90095
Tel: 310-825-8896
Fax: 310-206-5553
Email: gcheng@mednet.ucla.edu


Affiliations:
UCLA ACCESS
David Geffen School of Medicine
Jonsson Comprehensive Cancer Center (JCCC)
California NanoSystems Institute (CNSI)

Education:
1985-1990 Ph.D., Molecular Biology
Albert Einstein College of Medicine, New York, NY
Mentor: Professor Arthur I Skoultchi

1980-1984 B.S., Cell Biology
Wuhan University, China

Research Experience:
2005-present: Professor
Dept. of Microbiology, Immunology & Molecular Genetics
University of California, Los Angeles

Research Interests:Signaling via the TNFR, Nod and TLR families, Host defense against bacterial and viral infections, Cancer vaccine, inflammatory and metabolic diseases


2002-2005: Associate Professor
Dept. of Microbiology, Immunology and Molecular Genetics
University of California, Los Angeles
Research Interests: Signal transduction via the TNFR and TLR families, Mouse models for the innate and adaptive immune response, Mechanisms for chemoresistance in cancer treatment

1996-2001: Assistant Professor
Dept. of Microbiology and Molecular Genetics
University of California, Los Angeles
Research Interests: Signal transduction via the TNFR and TLR families

1994-1996: Postdoctoral Fellow
Massachusetts Institute of Technology, Cambridge
Mentor: David Baltimore
Research Interests: Signal transduction in B lymphocyte activation

1992-1994: Postdoctoral Fellow
The Rockefeller University, New York, NY
Mentor: David Baltimore
Research Interests: Signal transduction in B lymphocyte activation

1990-1992: Postdoctoral Associate
Albert Einstein College of Medicine, New York, NY
Mentor: Arthur I. Skoultchi
Research Interests: Erythroleukemia cell differentiation, oncogenes

Awards:
2005 The Leukemia & Lymphoma Society Stohlman Scholar
2000-2005 Scholar Award from the Leukemia & Lymphoma Society
1999 Frontiers of Science Award
1996-1999 Stop Cancer Award
1992-1996 Postdoctoral Fellowship from the Irvington Institute for Medical Research
1985-1990 CUSBEA (China and United States Biochemistry and Molecular Biology Examination and Application) graduate student training program

Invited Speeches:

April, 1997 “TRAF Proteins as Adapters for TNF Receptor Signaling”, Cambridge Symposia,
Santa Fe, New Mexico

Sept., 1997 “Signaling through the TNF Receptor Superfamily”, meeting on “Selected
Signaling/Transcription Pathways Involved in Human Diseases - Opportunities of
Novel Drug Targets and Biological Models”, Ulm, Germany.

May, 1998 “TNF-Mediated Signal Transduction Pathway”, Cellegy Pharmaceuticals Inc.,
South San Francisco, California.

Jan., 1999 “Specificities of CD40 Signaling”, Burnham Institute, La Jolla, California.

June, 1999 “Molecular Dissection of CD40-Mediated Signal Transduction Pathways”,
Affymetrix Genechip, Inc., Santa Clara, California

Aug., 2000 “Signaling Through the TNF Receptor Superfamily”, meeting of “Frontiers of
Biological Sciences”, Beijing, China.

Oct., 2000 “NF-B-Dependent Upregulation of Bcl-2 Family Proteins in Cell Survival, Cell
Transformation and Chemoresistance”, University of California, Irvine

Dec., 2000 “Molecular Dissection of CD40-Mediated Immune and Inflammatory
Responses”, Gene Medicine seminar series of University of California, Los
Angeles

Jan., 2001 “Molecular Dissection of CD40-Mediated Immune and Inflammatory
Responses”, Rehab, Los Angeles, California

Jan., 2001 “Common Signaling Pathways Involved in Normal Immune Responses,
Abnormal Inflammatory, Cell Transformation and Chemoresistance”, University
of Southern California, Los Angeles

Jan., 2001 “How Signals Essential for Normal Immune Responses are Used in Abnormal
Inflammation, Cell Transformation and Chemoresistance”, University of California, Riverside.

March, 2001 “Signaling Through the TNF Receptor and Toll-Like Receptor Families”, Ear
Institute, Los Angeles, California

April, 2001 “Overlapping and Stimulus-Specific Global Activation Responses of Resting B
Cells to CD40L and LPS”, Keystone Symposia (Section Chair), Snowbird, Utah

June, 2001 “Molecular Dissection of CD40-Mediated Immune and Inflammatory
Responses”, meeting on “Frontiers of Biological Sciences in the 21st Century”,
Beijing, China

April, 2002 “Signaling and gene expression specificity in controlling innate and adaptive
immune responses”, Presented in the gene expression & signaling in the immune
system meeting at the Cold Spring Harbor Laboratory, New York.
April, 2002 “Signaling and gene expression specificity in controlling innate and adaptive immune responses”, Albert Einstein College of Medicine, New York.

May, 2002 “Signaling and gene expression specificity in controlling immune and inflammatory responses”, Oregon Health & Science University Search, Oregon

June, 2002 “Signal transduction pathways involved in immune and inflammatory responses
against bacterial and viral infections”, Amgen Inc., California.

July, 2002 “Signal transduction in immune system”, Xishan Immunology Conference, Suzhou, China

Sept., 2002 “Signal transduction pathways involved in immune and inflammatory responses
against bacterial and viral infections”, New York University Immunology Club Seminar Series, New York.

Oct., 2002 “TRAF3: a positive or negative signaling regulator for the TNFR superfamly”, 9th
International Congress on TNF-Related Cytokines, San Diego, California.

May, 2003 “Signaling Specificity among Toll-Like Receptors”, Immunology Club Seminar
Series, Mount Sinai School of Medicine, New York.

June, 2003 “The IRF3-mediated gene program in antiviral innate immunity”, NIAID
workshop on Antiviral Innate immunity: Recognition, Defenses, Evasion, and BioDefense Strategies, NIH, Maryland.

Aug., 2003 “Ying-Yang Balance in Host Defense against Infections and Cancers”, Zhang
Jing Hi-tech park, Shanghai, China

Oct., 2003 “TLR-mediated innate immune responses against bacterial and viral infections”,
Immunology seminar series, University of Pennsylvania School of Medicine, PhiladelphiA

Nov., 2003 “TLR-mediated innate immune responses against bacterial and viral infections”,
Department of Immunology, University of Tokyo, Tokyo, Japan

Nov., 2003 “Signal Transduction and Gene Expression Network in TLR-Mediated Innate
Immune Responses”, International Symposium on Regulation Networks of
Eukaryotic Gene Expression, Waseda University International Conference Center,
Tokyo, Japan

Jan., 2004 “Gene programs involved innate immune responses against bacterial and viral
infections”, Immunology seminar series, U.T. MD Anderson Cancer Center,
Houston

May, 2004 “Signaling specificity during innate and adaptive immune responses”, Institute of
Immunology, Second Military Medical University, Shanghai, China

May, 2004 "Innate Immune Responses against Bacterial and Viral Infections", the CURE
AstraZeneca Lecture Series, VA Greater LA Healthcare System, Los Angeles.

July, 2004 “Innate immunity to infections”, 1st International Symposium on Infection and
Immunity (Meeting Co-Chair), Beijing
July, 2004 “Singaling pathways in immune and inflammatory responses”, 10th SCBA
International Symposium (Section Chair), Beijing

Oct., 2004 “Opposing role of type I interferon in host innate immune responses against viral
and bacterial infections”, The 30th Annual La Jolla Immunology Conference, The
Salk Institute, La Jolla, California

Oct., 2004 “Combating bacterial pathogens through host defense gene program”,
Immunology seminar series, University of California San Francisco, California

Oct., 2004 “Combating bacterial pathogens through host defense gene program”,
Immunology seminar series, University of California Berkeley, California

Dec., 2004 “Defeating Pathogens through Host Defense Gene Programs”, Ohio State
University Medical Center, Columbus, Ohio

Mar., 2005 “Host defense against bacterial and viral infections”, Department of Pediatrics,
UCLA, Los Angeles, California

Mar., 2005 "Regulation of TLR-mediated immune and inflammatory responses through TGFbeta/Type I interferon crosstalk"; CURE: DDRC 2005 Annual Research Meeting,
Los Angeles, California

April, 2005 “TLR-mediated innate immune gene program against bacterial and viral
infections”; The 3rd Congress of the Federation of Immunology Societies of Asia-
Oceania (Section Chair), Hangzhou, China

April, 2005 “Tradditional Medicine in Regulation of Immune Response”; The 3rd Congress of
the Federation of Immunology Societies of Asia-Oceania (Section Chair),
Hangzhou, China

June, 2005 “Innate Immune Gene Programs in Host Defense against Bacterial and Viral
Infections”, Department of Immunology, Cleveland Clinic Foundation
Cleveland, Ohio

Sept., 2005 “Balance between immune and inflammatory responses”; Enzo Biochem Inc.,
New York

Sept., 2005 “The role of TRAF3 in antiviral and anti-inflammatory responses”; Albert
Einstein College of Medicine, New York

Oct., 2005 “Critical role of TRAF3 in TLR-dependent type I interferon production”, The
2005 Annual Meeting of the International Society for Interferon and Cytokine
Research (ISICR), Shanghai, China.

Oct., 2005 “Crosstalks between Innate immune responses and host metabolisms”,
Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences,
Guangzhou, China

Nov., 2005 “Innate Immune Gene Programs in Host Defense against Bacterial and Viral
Infections”, Immunology seminar series, University of Chicago, Chicago, IL
60637

Dec., 2005 “Innate Immune Gene Programs in Host Defense against Bacterial and Viral
Infections”, Gene therapy seminar series, Baylor College of Medicine, Houston,
Texas.

Feb., 2006 “My D88-Mediated Neutrophil Recruitment in Immunity Against Staphylococcus
Aureus”, the 29th Annual MidWinter Meeting (Association For Research In
Otolaryngology), Baltimore, Maryland.

Mar., 2006 “Type I interferon gene program in host defense against viral and bacterial
infections”, The Toll 2006 meeting, Brazil.

Mar., 2006 “Rescue of TRAF3 null mice by p100 deficiency”, NF-kB: 20 years on the road
from Biochemistry to Pathology, Keystone Symposia, Banff, Canada.

May, 2006 “Crosstalk in host responses to infections and metabolic challenges”, Genentech
Inc., San Francisco.

May, 2006 “Dual roles of TRAF3 in anti-inflammatory and anti-viral responses”, Amgen
Inc., San Francisco

May, 2006 “Interferon and Resistance to Bacterial Infections”, 106th American Society for
microbiology general meeting, Orlando, Florida

May, 2006 “Crosstalk in host response to bacterial and viral infections”, Immunology
seminar series, Duke University.

May, 2006 “Innate Immune Gene Program against Bacteria and Viral Infections”,
Department of Microbiology and Immunology seminar program, The University
of North Carolina at Chapel Hill.

July, 2006 “Host Interferon Response to Viral Infection”, the 11th SCBA International
Symposium, San Francisco

Sept., 2006 “CD40L and LPS induced signaling and gene expression network”, Biochemistry
seminar series, UCSD, San Diego, California

Oct., 2006 “Innate immune responses and cancer vaccine”, JCCC cancer center seminar
UCLA, Los Angeles, California

Nov., 2006 “Signaling and gene expression programs involved in immune and inflammatory
responses”, Amgen, California

Nov., 2006 “Crosstalk between innate immune response to viral infection and host
metabolism”, Joint meeting of the Society for Leukocyte Biology and the
International Endotoxin and Innate Immunity Society, San Antonio

Dec., 2006 “Multiple Interferon Induction Pathway”, 36th Japanese Society of Immunology
Conference, Osaka, Japan

Jan., 2007 “Contribution of the Interferon/Jak/STAT pathway to the specificity of TLRmediated
gene programs”, The Jak/STAT keystone symposia, Steamboat Springs, Colorado

Mar., 2007 “Innate Anti-Bacterial and Anti-Viral Gene Programs and their Crosstalk with
Host Metabolism”, Pharmacology seminar series, UCSD, San Diego

May, 2007 “Innate Immune Response to Bacterial and Viral Infections”, University of
Michigan, Ann Arbor, MI

June, 2007 “Crosstalk between Host Innate Response and Metabolism”, International BioEco
2007, Tianjin, China

July, 2007 “IL-1β/IL-1R-mediated neutrophil recruitment gene program in host defense
against Staphylococcus aureus infection”, International Conference on Immunology 2007, Shanghai, China

July, 2007 “Innate immune gene programs against bacterial and viral infections”,
Symposium: Frontiers in Biological Sciences, Tsinghua University, Beijing,
China.

Sept., 2007 “The impact of Type I Interferon Induction pathways on Anti-Bacterial,
Inflammatory Responses and Host Metabolisms”, Yale University, CT

Sept. 2007 “The impact of Type I Interferon Induction pathways on Anti-Bacterial,
Inflammatory Responses and Host Metabolisms”, University of Southern
California, Los Angeles, CA

Oct., 2007 “Crosstalk in host defense against bacterial and viral infections”, Molecular
Biology Institute, UCLA, Los Angeles, CA

Nov., 2007 “The impact of Type I Interferon Induction pathways on Anti-Bacterial,
Inflammatory Responses and Host Metabolisms”, La Jolla Institute for Allergy &
Immunology, La Jolla, CA

Jan., 2008 “Regulation of Hepatotoxicity through IRF3-RXR Crosstalk”, Hepatic
Inflammation and Immunity 2008, Galveston, TX

Feb., 2008 “TRAF3, a Critical Negative Regulator of both Classic and Alternative NF-kB
Activation”, Keystone Symposia, Fairmont Banff Springs, Banff, Alberta, Canada

Mar., 2008 “TRAF3, NF-kB and Beyond”, Caltech, CA

May, 2008 “Innate Immune Gene Programs”, Stanford, CA

June, 2008 “The TRIF-dependent type I IFN induction pathway negatively regulates Th17-
mediated autoimmune inflammation”, Institute of Biophysics, Chinese Academic
of Science, Beijing
.
July, 2008 The TRIF-dependent type I IFN induction pathway negatively regulates Th17-
mediated autoimmune inflammation”, 302 Hospital, Beijing.

Sept, 2008 Type I Interferon Gene Programs Beyond Anti-Virus”, UC Berkeley, CA

Oct., 2008 “Three Zinc Ring Ubiquitin Ligases in the NIK Degradation complex”, 2008
cytokine meeting, Montreal, Canada.

Oct., 2008 “Influenza-induced type I interferons suppress host defense against secondary
bacterial pneumonia”, Second International Symposium of Infection and Immunity, Beijing.

Nov., 2008 Type I Interferon Gene Programs Beyond Anti-Virus”, The 6th Chinese Society of
Immunology, Xi”An , China

Nov., 2008 Type I Interferon Gene Programs Beyond Anti-Virus”, Caltech, CA

Jan., 2009 Role of TRAF3 in type I interferon responses to DNA and RNA viruses,
University of Miami, FL.

June, 2009 Immune mechanisms for postinfluenza bacterial pneumonias, the 12th SCBA
meeting, Section Chair, Taipei, Taiwan

June, 2009 Regulation of Type I Interferon Response to HIV Infection, The 3rd International
symposia of Infection and Immunity, Meeting organizer, Lijiang, China.

July, 2009 Signaling complexes involved in NF-kB and IRF3 activation, The 1st symposia of
structural Immunology, Meeting organizer, Beijing, China.

July, 2009 Type I interferon suppresses neutrophil recruitment as a potential mechanism of
Influenza Pneumonia, Xi”An , China

July, 2009 Innate Immune Gene Programs Against Bacterial and Viral Infections, Zhejiang
University, Zhejiang, China

Sept, 2009 Crosstalk of Host Innate Immune Responses and Nuclear Receptors, The Henry
M. and Lillian Stratton Basic Research Single Topic Conference, Atlanta,
Georgia

Dec. 2009 Innate Immunity against Bacterial and viral infections. The CBIS meeting, La
Jalla, CA

March, 2010 Innate Immune Gene Programs against Bacterial and Viral Infections, Shanghai,
China

April, 2010 Innate immune gene programs against bacterial and viral infections and their
crosstalk to host metabolisms and cancers, MIT Biology Colloquium, MIT, Boston, MA

May, 2010 Host Immune and Inflammatory Responses to Infections, 4th Pasteur-Areva Course on Anti-viral Immunity, Shanghai, China

May, 2010 Innate immunity in tumor surveillance and treatment, Sun Yat-Sen University,
Guangzhou, China

May, 2010 Type I interferon response to viral infections, Immunology Mini-symposium,
Guangzhou, China

May, 2010 Type I interferon beyond antiviral activity, Zhejiang University, Zhejiang, China
June, 2010 Role of TRAF3 in innate and inflammatory responses, MD Anderson Cancer
Canter, Texas

June, 2010 Hematopoiesis triggered by PAMPs and DAMPs, Cell, DNA, and Tissue
Damage and Responses Symposium, Riverside, CA

Auhust, 2010 Understand and control Infectious Diseases through Host-Pathogen Interactions,
international structural immunology symposium (meeting organizer), Inner Mongolia, China.

Auhust, 2010 Application of nanotechnology in the detection and treatment of infectious
diseases, IEEE NANO 2010 (Section Chair), Seoul, South Korea.

Sept., 2010 Innate Immune Gene Programs Against Bacterial and Viral Infections and Their
Crosstalk to Inflammatory and Metabolic Diseases. University of Pennsylvania, Philadelphia, PA

Oct., 2010 Crosstalk between innate immune responses and host metabolisms, Chinese
Society of Immunology symposium, Beijing

Nov., 2010 Involvement of TRAF3 in innate immune and inflammatory responses, cold
strong harbor immunology meeting

Nov. 2010 The type I interferon gene program in host anti-inflammatory responses, The 1st
symposium of cell and molecular immunology, Hefei