Black Lab Publications

39. Sharma S, Kohlstaedt L, Damianov A, Rio D, and Douglas L. Black. Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome. Nature Structural and Molecular Biology 15( 2): 183-9 (2008).
38. Li Q, Lee JA, and Douglas L. Black. Neuronal regulation of alternative pre-mRNA splicing. Nature Reviews Neuroscience. 8(11): 819-31 (2007).
37. Boutz P, Stoilov P, Li Q, Lin C, Chawla G, Ostrow K, Shiue L, Manuel C. Ares and Douglas L. Black. Post-transcriptional regulatory switchin polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Genes and Development. 21(13):1636-52 (2007).
36. Lee J, Xing Y, Nguyen D, Xie J, Lee C. and Douglas L. Black. Depolarization and CaM Kinase IV Modulate NMDA Receptor Splicing through Two Essential RNA Elements. PLoS Biology, 5(2):e40 (2007).
35. Boutz P, Chawla G, Stoilov P, and Douglas L. Black. MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development. Genes and Development, 21(1):71-84 (2007).
34. Sharma S, and Douglas L. Black. Maps, Codes, and Sequence Elements: Can We Predict the Protein Output from an Alternatively Spliced Locus? Neuron, 52(4):574-576 (2006)
33. Douglas L. Black and Brenton R. Graveley. Splicing bioinformatics to biology. Genome Biology 7(5):317 (2006).
32. Auweter, Sigrid, Fasan R, Luc Reymond, Jason Underwood, Douglas L Black, StefanPitsch  and Frédéric H-T Allain . Molecular basis of RNA recognition by the human alternative splicing factor Fox-1. The EMBO Journal, 25(1):163-73 (2006)
31. Xie J., Jan C., Stoilov P., Park J. and Black, D.L. A consensus CaMK IV-responsive RNA sequence mediates regulation of alternative exons in neurons. RNA, 11(12):1825-1834 (2005)
30.
Underwood J., Boutz P., Dougherty, J.D., Stoilov P. and Black, D.L. Homologues of the C. Elegans Fox-1 Protein are neuronal splicing regulators in mammals.
Mol and Cell Biol, 25(22):10005-16 (2005).
29. Oberstrass, Florian C., Sigrid D. Auweter , Michèle Erat, Yann Hargous, Anke Henning, PhilippWenter, Luc Reymond, Batoul Amir-Ahmady, Stefan Pitsch, Douglas L. Black, Frédéric H.-T.Allain . Structure of PTB bound to RNA: specific binding and implications for splicing regulation. Science 309(5743):2054-7 (2005).
28.
Sharma S., Falick A.M., and Black D.L. Polypyrimidine Tract Binding Protein Blocks the 5' Splice Site-Dependent Assembly of U2AF and the Prespliceosomal E Complex.
 Molecular Cell, 19(4):485-96 (2005).
27.
Amir-Ahmady B., Boutz P., Markovtsov V., Phillips M.L., and Black D.L. Exon Repression by Polypyrimidine Tract Binding Protein.
RNA, 11(5):699-716 (2005).
26.
Black, Douglas L., A simple answer for a splicing conundrum.
 Proceedings of the National Academy of Sciences, USA 104(14):4927-8 (2005).
25. Hall, Megan P., Sui Huang and Douglas L. Black, Differentiation-induced Colocalization of the KH-type Splicing Regulatory Protein with Polypyrimidine Tract Binding Protein and the c-src Pre-mRNA. Molecular Biology of the Cell, 15:774-786 (2004)
24. Xie, Jiuyong, Ji-Ann Lee, Tracy L. Kress, Kimberly L. Mowry and Douglas L. Black. Protein Kinase A phosphorylation modulates transport of the polypyrimidine tract-binding protein. Proceedings of the National Academy of Sciences, USA 100(15): 8776-8781 (2003)
23. Rooke, Nanette, Vadim Markovtsov, Esra Cagavi, Doulgas L. Black. Roles for SR proteins and hnRNP A1 in the regulation of c-src exon N1. Mol and Cell Biol, 23(6):1874-1884 (2003).
22. Black, Douglas L., Mechanisms of Alternative Pre-Messenger RNA Splicing.

Annual Review of Biochemistry, Vol 72. (2003)
21. Black, Douglas L. and Paula J. Grabowski. Alternative pre-mRNA splicing and neuronal function. Chapter in: Progress in Molecular and Subcellular Biology, Vol. 31(P.Jeantuer, ed.).

Springer-Verlag Berlin Heidelberg. (2003)
20. Grabowski, Paula J. and Douglas L. Black. Alternative RNA splicing in the nervous system. Progress in Neurobiology, 65(3):289-308 (2001).
19. Xie, Jiuyong and Douglas L. Black. A CaMK IV-responsive RNA element mediates depolarization-induced alternative splicing of potassium channels. Nature, 410:936-939 (2001).
18. Black, Douglas L. Protein diversity from alternative splicing: a challenge for bioinformatics and post-genome biology. Cell, 103(3):367-370 (2000).
17. Markovtsov, Vadim, Julia M. Nikolic, Joseph A. Goldman, Christoph W. Turck, Min-Yuan Chou, and Douglas L. Black. Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine-tract binding protein. Mol and Cell Biol 20(20):7463-7479 (2000).
16. Chou, Min-Yuan, Jason G. Underwood, Julia Nikolic, Martin H. T. Luu and Douglas L. Black. Multisite binding and release of polypyrimidine tract binding protein during the regulation of c-src neuralspecific splicing. Molecular Cell, 5:949-957 (2000).
15. Modafferi, Edward F., and Douglas L. Black Combinatorial control of a neuron-specific exon. RNA 5: 687-706 (1999).
14. Ring, Huijun Z., Vida Vameghi-Meyers, Julia M. Nikolic, Hosung Min, Douglas L. Black, and Uta Francke. Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17. Genomics 56: 350-352 (1999).
13. Ring, Huijun Z., Vida Vameghi-Meyers, Hosung Min, Julia M. Nikolic, Douglas L. Black, and Uta Francke. The mouse Fubp gene maps near the distal end of chromosome 3. Genomics 56: 357-358 (1999).
12. Chou, Min-Yuan, Nanette Rooke, Christoph W. Turck, Douglas L. Black. HnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells. Mol Cell Biol 19(1): 69-77 (1999).
11. Black, Douglas L. Splicing in the inner ear: a familiar tune, but what are the instruments? Neuron, 20(2): 165-168 (1998).
10. Wei, Nan, Claudia Q. Lin, Edward F. Modafferi, William A. Gomes, and Douglas L. Black. A unique intronic splicing enhancer controls the inclusion of the agrin Y exon. RNA 3: 1275-1288 (1997).
9. Modafferi, Edward F., and Douglas L. Black. A complex intronic splicing enhancer from the c-src pre-mRNA activates inclusion of a heterologous exon. Mol Cell Biol 17(11): 6537-6545 (1997).
8. Chan, Raymond C., and Douglas L. Black. The polypyrimidine tract binding protein binds upstream of neural cell-specific c-src exon N1 to repress the splicing of the intron downstream. Mol Cell Biol 17(8): 4667-4676 (1997).
7. Min, Hosung, Christoph W. Turck, Julia M. Nikolic, and Douglas L. Black. A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer. Genes Dev 11, 1023-1036 (1997).
6. Black, Douglas L., Raymond C. Chan, Hosung Min, Jiwa Wang, and Leslie Bell. The electrophoretic mobility shift assay for RNA binding proteins. Chapter in "RNA-Protein Interactions: A Practical Approach." Oxford University Press, Oxford, UK (1997).
5. Black, Douglas L. Finding splice sites within a wilderness of RNA. RNA 1, 763-771 (1995).
4. Min, Hosung, Raymond C. Chan, and Douglas L. Black. The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event. Genes Dev 9, 2659-2671 (1995).
3. Chan, Raymond C., and Douglas L. Black. Conserved intron elements repress splicing of a neuron-specific c-src exon in vitro. Mol Cell Biol 15, 6377-6385 (1995).
2. Black, Douglas L. Activation of c-src neuron-specific splicing by an unusual RNA element in vivo and in vitro. Cell 69, 795-807 (1992).
1. Black, Douglas L. Does steric interference between splice sites block the splicing of a short c-src neuron-specific exon in non-neuronal cells? Genes Dev 5, 389-402 (1991).

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