Further Reading

See also our own publications.

General Splicing and the Spliceosome

C.L. Will and R. Lührmann
Spliceosome Structure and Function
Chapter in: The RNA World , Third Edition
Editors: Gesteland, R.F., T. R. Cech, and J. F. Atkins,
Cold Spring Harbor Press, USA, 2005

Brow DA.
Allosteric cascade of spliceosome activation.
Annu Rev Genet. 2002;36:333-60. Review.

Nilsen TW.
The spliceosome: the most complex macromolecular machine in the cell?
Bioessays. 2003 Dec;25(12):1147-9. Review.

Alternative Splicing

Black DL.
Mechanisms of alternative pre-messenger RNA splicing.
Annu Rev Biochem. 2003;72:291-336. Review.

Black DL, Grabowski PJ.
Alternative pre-mRNA splicing and neuronal function.
Prog Mol Subcell Biol. 2003;31:187-216. Review.

Shin C, Manley JL.
Cell signalling and the control of pre-mRNA splicing.
Nat Rev Mol Cell Biol. 2004 Sep;5(9):727-38. Review.

Matlin AJ, Clark F, Smith CW.
Understanding alternative splicing: towards a cellular code.
Nat Rev Mol Cell Biol. 2005 May;6(5):386-98. Review.

Lipscombe D.
Neuronal proteins custom designed by alternative splicing.
Curr Opin Neurobiol. 2005 Jun;15(3):358-63. Review

PTB

Spellman R. and Smith CW
Novel modes of splicing repression by PTB.
Trends in Biochemical Science. 2006.

Wagner EJ, Garcia-Blanco MA.
Polypyrimidine tract binding protein antagonizes exon definition.
Mol Cell Biol. 2001 May;21(10):3281-8. Review.

Fox Proteins

Meyer BJ.
Sex in the wormcounting and compensating X-chromosome dose.
Trends Genet. 2000 Jun;16(6):247-53. Review.

Jin Y, Suzuki H, Maegawa S, Endo H, Sugano S, Hashimoto K, Yasuda K, Inoue K.
A vertebrate RNA-binding protein Fox-1 regulates tissue-specific splicing via the pentanucleotide GCAUG.
EMBO J. 2003 Feb 17;22(4):905-12.

Shibata H, Huynh DP, Pulst SM.
A novel protein with RNA-binding motifs interacts with ataxin-2.
Hum Mol Genet. 2000 May 22;9(9):1303-13.

MicroRNA’s and RNA Interference

He L, Hannon GJ.
MicroRNAs: small RNAs with a big role in gene regulation.
Nat Rev Genet. 2004 Jul;5(7):522-31. Review.

Conditional Knockout Alleles of Splicing Factors in Mice

Xu X, Fu XD.
Conditional knockout mice to study alternative splicing in vivo.
Methods. 2005 Dec;37(4):387-92.

DNA Microarrays for detecting Alternative Splicing

Srinivasan K, Shiue L, Hayes JD, Centers R, Fitzwater S, Loewen R, Edmondson LR, Bryant J, Smith M, Rommelfanger C, Welch V, Clark TA, Sugnet CW, Howe KJ, Mandel-Gutfreund Y, Ares M Jr.
Detection and measurement of alternative splicing using splicing-sensitive microarrays.
Methods. 2005 Dec;37(4):345-359.

Ule J, Ule A, Spencer J, Williams A, Hu JS, Cline M, Wang H, Clark T, Fraser C, Ruggiu M, Zeeberg BR, Kane D, Weinstein JN, Blume J, Darnell RB.
Nova regulates brain-specific splicing to shape the synapse.
Nat Genet. 2005 Aug;37(8):844-52.

Pan Q, Shai O, Misquitta C, Zhang W, Saltzman AL, Mohammad N, Babak T, Siu
H, Hughes TR, Morris QD, Frey BJ, Blencowe BJ.
Revealing global regulatory features of mammalian alternative splicing using a
quantitative microarray platform.
Mol Cell. 2004 Dec 22;16(6):929-41.

Calcium Activated Potassium Channels

Lopez-Barneo J, Castellano A.
Multiple facets of maxi-k+ channels: the heme connection.
J Gen Physiol. 2005 Jul;126(1):1-5. Review.

Weiger TM, Hermann A, Levitan IB.
Modulation of calcium-activated potassium channels.
J Comp Physiol A 2002 Mar;188(2):79-87. Review.

Chen L, Tian L, MacDonald SH, McClafferty H, Hammond MS, Huibant JM, Ruth P, Knaus HG, Shipston MJ.
Functionally diverse complement of large conductance calcium- and voltage-activated potassium channel (BK) alpha-subunits generated from a single site of splicing.
J Biol Chem. 2005 Sep 30;280(39):33599-609.

Shipston MJ.
Alternative splicing of potassium channels: a dynamic switch of cellular excitability.
Trends Cell Biol. 2001 Sep;11(9):353-8.

NMDA Receptor Splicing

Zukin RS, Bennett MV.
Alternatively spliced isoforms of the NMDARI receptor subunit.
Trends Neurosci. 1995 Jul;18(7):306-13. Review.

Zhang L, Liu W, Grabowski PJ.
Coordinate repression of a trio of neuron-specific splicing events by the splicing regulator PTB.
RNA. 1999 Jan;5(1):117-30.

Okabe S, Miwa A, Okado H.
Alternative splicing of the C-terminal domain regulates cell surface expression of the NMDA receptor NR1 subunit.
J Neurosci. 1999 Sep 15;19(18):7781-92.

Standley S, Roche KW, McCallum J, Sans N, Wenthold RJ.
PDZ domain suppression of an ER retention signal in NMDA receptor NR1 splice variants.
Neuron. 2000 Dec;28(3):887-98.

Scott DB, Blanpied TA, Swanson GT, Zhang C, Ehlers MD.
An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing.
J Neurosci. 2001 May 1;21(9):3063-72.

Ule J, Darnell RB.
RNA binding proteins and the regulation of neuronal synaptic plasticity.
Curr Opin Neurobiol. 2006.