Former Lab Members & Friends of the Black Lab

Frédéric Allain

Postdoctoral Fellow
2000-2001

Subsequent Position:
Assistant Professor, ETH Zurich

• Oberstrass FC, Auweter SD, Erat M, Hargous Y, Henning A, Wenter P, Reymond L, Amir-Ahmady B, Pitsch S, Black DL, Allain FH. Structure of PTB bound to RNA: specific binding and implications for splicing regulation. Science 309(5743):2054-7 (2005).
• Auweter S, Fasan R, Reymond L , Underwood J, Douglas L Black, Pitsch S  and Frédéric H-T Allain. Molecular basis of RNA recognition by the human alternative splicing factor Fox-1. The EMBO Journal 25(1):163-73 (2006)

Ray Chan

Graduate Student
9/93 - 12/97

Subsequent Position:
Postdoctoral Fellow, UC Berkeley

Publications:

• Chan, Raymond C., and Douglas L. Black. Conserved intron elements repress splicing of a neuron-specific c-src exon in vitro. Mol Cell Biol 15, 6377-6385 (1995).
• Min, Hosung, Raymond C. Chan, and Douglas L. Black. The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event. Genes Dev 9, 2659-2671 (1995).
• Black, Douglas L., Raymond C. Chan, Hosung Min, Jiwa Wang, Leslie Bell. The electrophoretic mobility shift assay for RNA binding proteins. Chapter in "RNA-Protein Interactions: A Practical Approach." Oxford University Press, Oxford, UK (1997).
• Chan, Raymond C., and Douglas L. Black. The polypyrimidine tract binding protein binds upstream of neural cell-specific c-src exon N1 to repress the splicing of the intron downstream. Mol Cell Biol 17(8): 4667-4676 (1997).

Min-Yuan Chou

Postdoctoral Fellow
11/96 - 10/99

Subsequent Position:
Research Scientist, Industrial Tech Research Institute, Taiwan

Publications:

• Chou, Min-Yuan, Nanette Rooke, Christoph W. Turck, and Douglas L. Black. HnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells. Mol Cell Bio, 19(1): 69-77 (1999).
• Markovtsov, Vadim, Julia M. Nikolic, Joseph A. Goldman, Christoph W. Turck, Min-Yuan Chou, and Douglas L. Black. Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine-tract binding protein. Mol and Cell Biol 20(20):7463-7479 (2000).
• Min-Yuan Chou, Jason G. Underwood, Julia Nikolic, Martin H. T. Luu and Douglas L. Black. Multisite binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing. Molecular Cell, 5:1-20 (2000).

Sarah Clark

Undergraduate
4/05 - 5/07

Subsequent Position:
Medical Student, Northwestern Universtiy Medical School

Aaron Goldman

Research Technician
9/00 - 8/01

Subsequent Position:
Graduate Student, Harvard Medical School

Publications:

• Markovtsov, Vadim, Julia M. Nikolic, Joseph A. Goldman, Christoph W. Turck, Min-Yuan Chou, and Douglas L. Black. Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine-tract binding protein. Mol and Cell Biol 20(20):7463-7479 (2000).

William A. Gomes

Research Technician
7/92 - 7/94

Megan Hall

Graduate Student
9/97 - 12/03

Subsequent Position:
Postdoctoral Fellow, SUNY Buffalo

Publications

• Hall, Megan P., Sui Huang and Douglas L. Black, Differentiation-induced Colocalization of the KH-type Splicing Regulatory Protein with Polypyrimidine Tract Binding Protein and the c-src Pre-mRNA. MBC 15:774-786 (2004).

Publications

• Xie J.,. Jan C, Stoilov P., Park J. and Black, D.L. A concensus CaMK IV-responsive RNA sequence mediates regulation of alternative exons in neurons. RNA, 11(12):1825-1834 (2005).

Claudia Q. Lin

Postdoctoral Fellow
11/94 - 8/95

• Wei, Nan, Claudia Q. Lin, Edward F. Modafferi, William A. Gomes, and Douglas L. Black. A unique intronic splicing enhancer controls the inclusion of the agrin Y exon. RNA 3: 1275-1288 (1997).

Publications:

Vadim Markovtsov

Postdoctoral Fellow
9/96 - 7/01

Current Position:
Staff Scientist, Rigel Corporation

• Markovtsov, Vadim, Julia M. Nikolic, Joseph A. Goldman, Christoph W. Turck, Min-Yuan Chou, and Douglas L. Black. Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine-tract binding protein. Mol and Cell Biol 20(20):7463-7479 (2000).
• Rooke, Nanette, Vadim Markovtsov, Estra Cagavi, Douglas L. Black. Roles for SR Proteins adn hnRNP A1 in the regulation of c-src exon N1. Mol Cell Bio, 23(6):1874-1884 (2003).

Hosung Min

Graduate Student
9/93 - 6/97

Current Position:
Principal Scientist
Department of Protein Science.
Amgen, Inc.

• Min, Hosung, Raymond C. Chan, and Douglas L. Black. The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event. Genes Dev 9, 2659-2671 (1995).
• Black, Douglas L., Raymond C. Chan, Hosung Min, Jiwa Wang, and Leslie Bell. The electrophoretic mobility shift assay for RNA binding proteins. Chapter in "RNA-Protein Interactions: A Practical Approach." Oxford University Press, Oxford, UK (1997).
• Min, Hosung, Christoph W. Turck, Julia M. Nikolic, and Douglas L. Black. A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer. Genes Dev 11, 1023-1036 (1997).
• Ring, Huijun Z., Vida Vameghi-Meyers, Hosung Min, Julia M. Nikolic, Douglas L. Black, and Uta Francke. The mouse Fubp gene maps near the distal end of chromosome 3. Genomics 56: 357-358 (1999).
• Ring, Huijun Z., Vida Vameghi-Meyers, Julia M. Nikolic, Hosung Min, Douglas L. Black, and Uta Francke. Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17.Genomics 56: 350-352 (1999).

Edward Modafferi

Graduate Student
9/93 - 7/99

Subsequent Position:
Postdoctoral Fellow, UC Irvine

Publications:

• Modafferi, Edward F., and Douglas L. Black. A complex intronic splicing enhancer from the c-src pre-mRNA activates inclusion of a heterologous exon. Mol Cell Biol. 17(11): 6537-6545 (1997).
• Wei, Nan, Claudia Q. Lin, Edward F. Modafferi, William A. Gomes, and Douglas L. Black. A unique intronic splicing enhancer controls the inclusion of the agrin Y exon. RNA 3: 1275-1288 (1997).
• Modafferi, Edward F., and Douglas L.Black. Combinatorial control of a neuron-specific exon. RNA 5: 687-706 (1999).

Shoba Narayan

David Nguyen

Undergraduate
4/05 - 5/07

Publications

• Lee J, Xing Y, Nguyen D, Xie J, Lee C. and Douglas L. Black. “Depolarization and CaM Kinase IV Modulate NMDA Receptor Splicing through Two Essential RNA Elements.” PLoS Biology 5(2):e40 (2007).

Kristin Ostrow

Publications

• Boutz P, Stoilov P, Li Q, Lin C, Chawla G, Ostrow K, Shiue L, Manuel C. Ares and Douglas L. Black. “Post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons.” Genes and Development. 21(13):1636-52 (2007).

Sara Panahandeh

Undergraduate
4/01 - 5/02

Subsequent Position:
Medical Student, Albany Medical School

Jennifer Park

Research Technician
12/00 - 8/03

Publications

• Xie J., Jan C., Stoilov P., Park J. and Black, D.L. A concensus CaMK IV-responsive RNA sequence mediates regulation of alternative exons in neurons. RNA, 11(12):1825-1834 (2005).

Publications

• Chou, Min-Yuan, Nanette Rooke, Christoph W. Turck, Douglas L. Black. HnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells. Mol Cell Bio, 19(1): 69-77 (1999).
• Rooke, Nanette, Vadim Markovtsov, Estra Cagavi, Douglas L. Black. Roles for SR Proteins and hnRNP A1 in the regulation of c-src exon N1. Mol Cell Bio, 23(6) (2003).
• Rooke Nanett.and Underwood Jason. In vitro RNA splicing in mammalian cell extracts (2003), Bonifacino J, Dasso M, Harford J, Lippincott-Schwartz J., Yamada K, Editors, 2005 Current Protocols in Cell Biology, John Wiley and Sons, Inc., Hoboken, NJ.

Hideshiro Saito- Benz

Undergraduate
6/02 - 7/02

Subsequent Position:
Graduate Student, MIT

Jason Underwood

Graduate Student
7/97 - 6/05

Subsequent Position:
Adjunct Professor, Occidental College

• Min-Yuan Chou, Jason G. Underwood, Julia Nikolic, Martin H. T. Luu and Douglas L. Black. Multisite binding and release of polypyrimidine tract binding protein during the regulation of c-src neuralspecific splicing. Molecular Cell, 5:949-957 (2000).
• Underwood J., Boutz P., Dougherty, J.D., Stoilov P. and Black, D.L. Homologues of the C. Elegans Fox-1 Protein are neuronal splicing regulators in mammals. Mol and Cell Biol, 25(22):10005-16 (2005).
• Rooke Nanette.and Underwood Jason. In vitro RNA splicing in mammalian cell extracts (2003), Bonifacino J, Dasso M, Harford J, Lippincott-Schwartz J., Yamada K, Editors, 2005 Current Protocols in Cell Biology, John Wiley and Sons, Inc., Hoboken, NJ.

Vida Vameghi-Meyers

Research Technician
1/95 - 6/96

• Ring, Huijun Z., Vida Vameghi-Meyers, Hosung Min, Julia M. Nikolic, Douglas L. Black, and Uta Francke. The mouse Fubp gene maps near the distal end of chromosome 3. Genomics 56: 357-358 (1999).
• Ring, Huijun Z., Vida Vameghi-Meyers, Julia M. Nikolic, Hosung Min, Douglas L. Black, and Uta Francke. Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17. Genomics 56: 350-352 (1999).

Nan Wei

Research Technician
7/94 - 2/97

Subsequent Position:
Research Technician, Amgen Corporation

Robin Yang

Undergraduate
6/98 - 7/99

Subsequent Position:
Medical Student, Washington University Medical School

Jiuyong Xie

Postdoctoral Fellow
12/98 - 11/03

Subsequent Position:
Assistant Professor, University of Manitoba

• Xie, Jiuyong and Douglas L. Black. "A CaMK IV-responsive RNA element mediates depolarization-induced alternative splicing of ion channels." Nature, 2001Apr 19;410(6831):936-939.
• Xie, Jiuyong, Ji-Ann Lee, Tracy L. Kress, Kimberly L. Mowry, and Douglas L. Black. "Protein Kinase A phosphorylation modulates transport of the polypyrimidine tract-binding protein". Proceedings of the National Academy of Sciences, USA 100(15): 8776-8781 (2003)
• Xie J., Jan C., Stoilov P., Park J. and Black, D.L. A concensus CaMK IV-responsive RNA sequence mediates regulation of alternative exons in neurons. RNA, 11(12):1825-1834 (2005) .