Recent Publications

Round, J.L., Humphries,L.A., Tomassian, T., Mittelstadt, P. Zhang, M., Miceli, M.C.  (2006)  Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors.  Nature Immunology  8: 154-61.

Round, J.L., Tomassian, T., Zhang, M., Patel, V., Schoenberger, S.P., Miceli, M.C.  (2005)  Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells.  Journal of Experimental Medicine  3:  419-30.

Zhang, M., Moran, M., Round, J., Low T.A., Patel, V.P., Tomassian, T., Hernandez, J.D., Miceli, M.C.  (2005)  CD45 signals outside of lipid rafts to promote ERK activation, synaptic raft clustering, and IL-2 production.  Journal of Immunology 174:  1479-90.

Huang, T.T., Zong, Y., Dalwadi, H., Chung, C., Miceli, M.C., Spicher, K., Birnbaumer L., Braun, J., Aranda, R.  (2003)  TCR-mediated hyper-responsiveness of autoimmune Galphai2(-/-) mice is an intrinsic naive CD4(+) T cell disorder selective for the Galphai2 subunit.  International Immunology 11:  1359-67.

Kersh E.N., Kaech S.M., Onami T.M., Moran M., Wherry E.J., Miceli, M.C., Ahmed, R.  (2003)  TCR signal transduction in antigen-specific memory CD8 T cells.  Journal of Immunology 170:  5455-63.

Brewer, C.F., Miceli, M.C., Baum L.G.  (2002)  Clusters, bundles, arrays and lattices: novel mechanisms for lectin-saccharide-mediated cellular interactions.  Current Opinion in Structural Biology 5:  616-23.

Kitchen, S.G., LaForge, S., Patel, V.P., Kitchen, C.M., Miceli, M.C., Zack, J.A. (2002)  Activation of CD8 T cells induces expression of CD4, which functions as a chemotactic receptor. Blood 99: 207-212.

Miceli, M.C., Moran, M., Chung, C.D., Patel, V.P., Low, T., Zinnanti, W. (2001)  Co-stimulation and counter-stimulation: lipid raft clustering controls TCR signaling and functional outcomes.  Seminars in Immunology 13: 115-28.

Patel, V.P., Moran, M., Low, T.A., Miceli, M.C. (2001)  A molecular framework for two-step T cell signaling:  Lck Src homology 3 mutations discriminate distinctly regulated lipid raft reorganization events.  Journal of Immunology 166: 754-64

Chung, CD, Patel, VP, Moran, M, Lewis, LA, and Miceli, M.C. (2000) Galectin-1 Induces Partial TCR zeta Chain Phosphorylation and Antagonizes Processive TCR Signal Transduction Processive. Journal of Immunology 165: 1758-66.

Vespa, G., Lewis L.A., Kozak K. R., Moran, M., Nguyen, J.T., Baum, L.G. and Miceli, M. C. (1999) Galectin-1 Specifically Modulates TCR Signals to Enhance TCR Apoptosis, but Inhibit IL-2 Production and Proliferation. Journal of Immunology 162:799-806.

Moran, M., Miceli, M.C. (1998)  Engagement of GPI-linked CD48 contributes to TCR signals and cytoskeletal reorganization: a role for lipid rafts in T cell activation.  Immunity 6: 787-96.

Lewis, L.A., Chung, C.D., Chen, J., Parnes, J.R., Moran, M.M., Patel, V.P. and Miceli, M. C. (1997) The Lck phosphotyrosine binding site is critical for efficient TCR-induced processive tyrosine phosphorylation of the zeta chain and IL-2 production. Journal of Immunology 159: 2292-2300. Journal of Immunology

Chung, C.D., Lewis, L.A., and Miceli, M.C. (1997) TCR-Induced IL-2 production and apoptosis have different requirements for Lck activities. Journal of Immunology 159:1758-66. Journal of Immunology