[D.A. Feldman's picture]

Lawrence T. Feldman, Ph.D.
Associate Professor
43-169 CHS


Administrative Support 
Leticia Fernandez 
Room 43-319 CHS 


Recent Selected Publications

1. Feldman, L.T., Imperiale, M.J. and Nevins, J.R. (1982) Activation of adenovirus transcription by herpesvirus immediate-early gene: evidence for a common cellular control factor. PNAS, 79:4952-4956.

 2. Ihara, S., Feldman, L.T., Watanabe, S., Ben-Porat, T. (1983) Characterization of the immediate-early functions of pseudorabies virus. Virol., 131:437-53.

 3. Feldman, L.T., Nevins, J.R. (1983) Localization of the adenovirus E1A protein, a positive acting transcriptional factor in infected cells. Mol. Cell. Biol., 3:829-38.

 4. Babich, A., Feldman, L.T., Nevins, J.R., Darnell, J.E., and Weinberger, C. (1983) Adenovirus infection stops the appearance and interrupts the translation of host cell mRNA. Mol. Cell. Biol., 3:1212-1221.

 5. Imperiale, M.J., Feldman, L.T., and Nevins, J.R. (1983) Activation of gene expression by adenovirus and herpes virus regulatory genes acting in trans and by a cis-acting adenovirus enhancer element. Cell, 35:127-135.

 6. Imperiale, M.J., Kao, H.T., Feldman, L.T., Nevins, J.R., and Srickland, S. (1984) Common control of the heat shock gene and early adenovirus genes: evidence for a cellular E1A-like activity. Mol. Cell. Biol., 4:867-74.7.

 7. Abmayr, S.M., Feldman, L.T., and Roeder, R.G. (1985) In vitro stimulation of specific RNApolymerase II-mediated transcription by the pseudorabies virus immediate-early protein. Cell, 43:821-829.

 8. Gaynor, R.B., Feldman, L.T., and Berk, A.J. (1985) Viral immediate early proteins activate transcription of class III genes. Science, 230:447-50.

 9. Feldman, L.T., Ahlers, S.E. (1986) Repression of adenovirus early gene expression by coinfection with a temperature sensitive mutant in the immediate-early gene of pseudorabies virus. J. Virol., 57:13-17. 10. Ahlers, S.E., Feldman, L.T. (1987a) Effects of a termperature sensitive mutation in the immediate-early gene of pseudorabies virus on class II and class III gene trascription. J. Virol., 61:1103-1107. 11. Ahlers, S.E., Feldman, L.T. (1987b) Immediate-early protein of pseudorabies virus is not continuously required to reinitiate transcription of induced genes. J. Virol., 61:1258-1260.

 12. Chlan, C.A., Coultar, C. and Feldman, L.T. (1987) Binding of the pseudorabies virus immediate-early protein to single stranded DNA. J.Virol., 61:1855-1860.

 13. Stevens, J.G., Wagner, E.K., Devi-Rao, G.B., Cook, M.L., and Feldman, L.T. (1987) RNAcomplementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons. Science, 235:1056-1059.

 14. Wagner, E.K., Devi-Rao, G., Feldman, L.T., Dobson, A.T., Zhang, Y., Flanagan, W.M. and Stevens, J.G. (1988) Physical Characterization of the Herpes Simplex Virus LatencyAssociated Transcript in Neurons. J. Virol., 62:1194-1202.

 15. Dobson, A.T., Sederati, F., Devi-Rao, G., Flanagan, W.M., Farrell, M.J., Stevens, J.G.,Wagner, E.K. and Feldman, L.T. (1989) Identification of the Latency-associated transcript promoter by expression of rabbit beta-globin mRNA in mouse sensory nerve ganglia infected with a recombinant herpes simplex virus. J. Virol., 63:3844-3851.

 16. Feldman, L.T. (1991) Molecular Biology of HSV-1 latency. In Herpesvirus transcription and its regulation. E.K. Wagner, ed. CRC Press, pp. 223-243.

 17. Dobson, A.T., Margolis, T.P., Sedarati, F., Stevens, J.G., and Feldman, L.T. (1990) A latent,nonpatholgenic HSV-1 derived vector stably expresses B-galactosidase in mouse neurons. Neuron, 5:353-360.

 18. Farrell, M.J., Bodson, A.T., and Feldman, L.T. (1990) Herpes simplex virus latency associated transcript is a stable intron. PNAS, 88:790-794.

 19. Margolis, T.P., Sedarati, F., Dobson, A.T., Feldman, L.T., and Stevens, J.G. (1992) Pathways of viral gene expression during acute neuronal infection with HSV-1. Virology, 188:150-160.

 20. Farrell, M.J., Hill, J.M., Margolis, T.P., Stevens, J.G., Wagner, E.K., and Feldman, L.T. (1993) The HSV type 1 reactivation function lies outside the LAT open reading frame ORF-2. J. Virology, 67:3653-3655.

 21. Deshmane, S.L., Nicosia, M., Valyi-Nagy, T., Feldman, L.T., Dillner, A., and Fraser, N.W. (1993) An HSV-1 mutant lacking the TATA element reactivates normally in axplant cocultivation. Virology, 196:868-872.

 22. Margolis, T.P., Bloom, D.C., Dobson, A.T., Feldman, L.T., and Stevens, J.G. (1993) Decreased reporter gene expression during latent infection with HSV LAT promoter constructs. Virology, 197:585-592.

 23. Farrel, M.J., T.P. Margolis, W.A. Gomes, and Feldman, L.T. (1994) Effect of the cap region on acute expression of the HSV-1 latency-associated transcript promoter. J. Virol., 68:5343-5887.

 24. Dobson, A.T., Margolis, T.P., Gomes, W.A., and Feldman, L.T. In vivo deletion analysis of the LAT promoter. J. Virol., 69:2264-2270.

 25. Lokensgard, J.R., Bloom, D., Dobson, A.T., and Feldman, L.T. Long term promoter expression during herpes simplex virus latency. J. Virol., 68:7148-7158.

 26. Bloom, D.C., Maidment, N.T., Feldman, L.T., and Stevens, J.G. (1994) Long term expression of a reporter gene from latent HSV in the rat hippocampus. Molecular Brain Research, 31:48-60.

 27. Bloom, D.C., Lokensgard, J.R., Maidment, N.T., Feldman, L.T., and Stevens, J.G. 1994. Long term expression of genes in vivo using non-replicating HSV vectors. Gene Therapy 1 Suppl.. 1:36-38.

 28. Dobson, A.T., Margolis, T.P., Gomes, W.A., and Feldman, L.T. 1995. In vivo deletion analysis of the LAT promoter. J. Virol. 69:2264-2270.

 29. Bloom, D.C., Maidment, N.T., Tan, A., Dissette, V.B., Feldman, L.T., and Stevens, J.G. 1995. Long term expression of a reporter gene from latent HSV in rat hippocampus. Mol. Brain Res. 31:48-60.

 30. Keir, S.D., Mitchell, W.J., Feldman, L.T., and Martin, J.R. 1995. Targeting and gene expression in spinal cord motor neurons following intramuscular inoculation of an HSV-1 vector. J. Neurovirology. 1:259-267.

 31. Bloom, D.C., Hill, J.M., Devi-Rao, G., Wagner, E.K., Feldman, L.T., and Stevens, J.G. 1996. A 348-base-pair region in the latency-associated transcript facilitates Herpes Simplex Virus Type 1 reactivation. J. Virol. 70:2449-2459.

 32. Maidment, N.T., Tan, A., Bloom, D.C., Anton, B., Feldman, L.T., and Stevens, J.G. Expression of the lacZ reporter gene in the rat basal forebrain, hippocampus, and nigro-straital pathway using a non-replicating HSV vector. 1996. Exp. Neurol. 139:107-114.

 33. Lokensgard, J.R., J. Berthomme, and Feldman, L.T. 1997 The latency-associated promoter of HSV-1 requires a region downstream of the transcription start site for long term expression during latency. J. Virology. IN PRESS.



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